نتایج جستجو برای: maltolate
تعداد نتایج: 96 فیلتر نتایج به سال:
Due to the antitumor activity of Gallium MAL complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. Ga-67 labeled 3-hydroxy-2-methyl-4H-pyran-4-onate (Ga-67 MAL) was prepared using freshly prepared Ga-67 chloride and 3-hydroxy-2-methyl-4H-pyran-4-onate in a...
Alzheimer's disease is multi-component neurodegenerative disorder. Oxidative stress disrupts regular functioning of metabolism in early-onset disease. It causes Tau phosphorylation, formation neurofibrillary tangle and neuron reduction. Due to intense binding phosphorylated amino acids aluminum, it induces self-assembly deposition high degree cytoskeletal proteins, such as microtubule neurofila...
Abstract BACKGROUND We previously reported on our in vitro and vivo studies using the metallocompound gallium maltolate (GaM) to target glioblastoma (GBM). demonstrated a profound cytotoxic effect vitrov vivo. Additionally, preliminary data suggested substantial inhibitory tumor growth, as well significant extension of disease-specific survival (OS). Here, we further validate effects GaM METHOD...
In the present study, the agonists and antagonists of DP receptor were used to examine whether the PGD2-DP signaling pathway affects neuronal function. Primary cultured hippocampal neuron was prepared and treated with aluminum maltolate (100 μM) to establish the neuronal damage model. PGD2 and cAMP content was detected by ELISA. L-PGDS and DPs mRNA and protein expression were measured by RT-PCR...
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