A six-year-old male castrated domestic shorthair cat was evaluated for a six-month history of haematochezia, mucoid diarrhoea, tenesmus and rectal prolapse. Colonic histopathology revealed multifocal mucosal ulceration lamina propria infiltration with large numbers periodic acid-Schiff-positive macrophages. Large clusters intracellular Escherichia coli were confirmed fluorescence in situ hybrid...

Maintaining quinolone concentrations outside the mutant selection window (MSW) between the MIC and mutant prevention concentration (MPC) was suggested by in vitro and in vivo studies to prevent the selection of resistant mutants. However, selection also may depend on the presence of resistant bacterial mutants at the start of treatment, which is highly dependent on the initial inoculum size. In...

1. Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands 2. Department of Pharmacology, Physiology and Chemistry, Faculty of Veterinary Medicine, Trakia University, Bulgaria 3. Department of Microbiology, Infectious and Parasitic Diseases, Section of Microbiology, Faculty of Veterinary Medicine, Trakia University, Bul...