This paper describes the development and application of a new unique tool to support designers to optimise the sustainability of urban neighbourhoods (SUNtool). In this the paper introduces (i) the software architecture, (ii) the integrated solver and related innovations in the modelling of radiation exchange, reduced thermal modelling, stochastic modelling of occupant presence and behaviour, a...

Pucung Village, Girisubo District, Gunung Kidul Regency needs a master plan, which is guideline for implementing the development of Village equipped with infrastructure, so that it contributes to achieving long-term vision. This study uses qualitative research methods, rationalistic approach. The number informants was 15 people, who were selected purposively. data consists of: (1) Primary data,...

Gereja Santo Yoseph Medari berada di daerah Kabupaten Sleman, Yogyakarta. ini memiliki kegiatan ibadat rutin (ekaristi mingguan) dan juga beberapa lainnya. Kegiatan tersebut antara lain rapat dewan, bidang, tim, pertemuan kelompok-kelompok kategorial, latihan-latihan misdinar, perjumpaan informal dalam upaya mempererat paguyuban umat. Kegiatan-kegiatan ada yang terjadwal, namun banyak pula insi...

Tanjung Bajau is a tourist area located in Sedau Village, South Singkawang District, City, West Kalimantan. one of the destinations Sinka Island Park. known as tour with very beautiful natural beauty, especially at sunset. That's because destination 2 parts, namely beach and mountain. However, better planning needed for tourism objects, facilities infrastructure, accessibility accommodation. Ba...

PURPOSE Standard treatment plan libraries are often used to ensure a quick turn-around time for vaginal cylinder treatments. Recently there is increasing interest in transitioning from conventional 2D radiograph based brachytherapy to 3D image based brachytherapy, which has resulted in a substantial increase in treatment planning time and decrease in patient through-put. We describe a novel tec...

In their article, Kesternich et al. [1] address the important topic of the shortage of general practitioners (GPs) and country doctors, which is considered in the “Masterplan Medizinstudium 2020” (master plan medical studies 2020) in the form of an admission quota for prospective country doctors. The study presents the results of a survey among medical students from Munich (Germany) in the clin...

AMP-activated protein kinase (AMPK) is a key molecular player in energy homeostasis at both cellular and whole-body levels. AMPK has been shown to mediate the metabolic effects of hormones such as leptin, ghrelin, adiponectin, glucocorticoids and insulin as well as cannabinoids. Generally, activated AMPK stimulates catabolic pathways (glycolysis, fatty acid oxidation and mitochondrial biogenesi...

E ukaryotic cells critically depend on the formation, budding, and scission of membrane-bounded vesicles for many key processes: internalization of cell surface receptors, delivery of cargo proteins to multivesicular bodies (MVBs) and lysosomes for degradation, transport of newly synthesized proteins between intracellular organelles and their delivery to the plasma membrane, and release of micr...