Few studies have used longitudinal approaches to consider the cumulative impact of COVID-19-related stressors (CRSs) on psychological adjustment mothers and children. In current study, we tracked changes in maternal depressive symptoms children’s behavioral problems from approximately 2 years before pandemic (T1) May through August 2020 (T2). Second, explored hair cortisol dehydroepiandrosteron...

Preeclampsia is a major cause of morbidity and mortality during pregnancy. Several independent investigators have demonstrated the association of androgens with hypertension. The main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. Serum levels of test...

background: 30% of patients with polycystic ovary syndrome (pcos) show mild, transient hyperprolactinemia. it is suggested that a reduction of the dopamine inhibitory effect might raise both prolactin and luteinizing hormone.objective: to investigate the adjuvant cabergoline therapy effects on menstrual irregularity and androgen system in pcos women with hyperprolactinemia.materials and methods...

objectives: this study designed to detect the prevalence of ovarian and/or adrenal hyperandrogenism in women with polycystic ovary syndrome (pcos).materials: one hundred pcos women included in this cross sectional study after informed consent and approval of the study by local institute ethical committee. diagnosis of pcos based on the rotterdam eshre criteria. studied women underwent complete ...

Dehydroepiandrosterone may influence thyroid function. Its metabolite, 7-oxo-dehydroepiandrosterone, a precursor of immunomodulatory 7-hydroxylated metabolites and thermogenic agent, belongs to candidates of steroid replacement therapy. The question was addressed whether its application does influence laboratory parameters of thyroid function. 7-Oxo-dehydroepiandrosterone in the form of emulgel...

CONTEXT Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations. The gene, SLC13A1, encodes the sodium-sulfate cotransporter NaS1, responsible for sulfate (re)a...

Acupuncture has been demonstrated to improve menstrual frequency and to decrease circulating testosterone in women with polycystic ovary syndrome (PCOS). Our aim was to investigate whether acupuncture affects ovulation frequency and to understand the underlying mechanisms of any such effect by analyzing LH and sex steroid secretion in women with PCOS. This prospective, randomized, controlled cl...

Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women. These diseases are estrogen dependent, and their progression often depends on local estrogen formation. In peripheral tissues, estrogens can be formed from the inactive precursors dehydroepiandrosterone sul...

OBJECTIVE To investigate body fat distribution in women with polycystic ovary syndrome (PCOS). METHODS Body weight, body mass index (BMI), and six indices of body fat measured by dual-energy x-ray absorptiometry were compared in 40 women with PCOS and 97 age-matched controls. The possible correlations between the body fat characteristics and serum androgen levels were evaluated in the 40 PCOS...