BACKGROUND: Nutritional problem is still a significant public health issue worldwide, and Indonesia not exempted. Stunting the failure of child to grow proper height their age due unbalance nutritional intake (more calories less protein) when they are in womb, baby, toddlers. The mother’s lack awareness about susceptibility severity stunting contributing factor. AIM: Purpose this study investig...

Maternal smoking in pregnancy (MSP) affects the offspring’s DNA methylation (DNAm). There is a lack of knowledge regarding individual differences susceptibility to exposure MSP. Glutathione S-transferase (GST) genes are involved protection against harmful oxidants such as those found cigarette smoke. This study aimed test whether polymorphisms GST influence effect MSP on offspring DNAm. Using d...

The expression of infectious disease is increasingly recognized to be impacted by maternal effects, where the environmental conditions experienced by mothers alter resistance to infection in offspring, independent of heritability. Here, we studied how maternal effects (high or low food availability to mothers) mediated the resistance of the crustacean Daphnia magna to its bacterial parasite Pas...

objective: to analyze the trend in maternal mortality ratio in a tertiary care centre and the effect of various maternity schemes on it. materials and methods:  retrospective analysis of all maternal deaths occurring in the guru gobind singh medical college & hospital, faridkot, punjab, india was done from jan 2010 to dec 2012. every maternal death was scrutinized from various aspects like dire...

Nondisjunction of chromosome 21 is the leading cause of Down syndrome. Two risk factors for maternal nondisjunction of chromosome 21 are increased maternal age and altered recombination. In order to provide further insight on mechanisms underlying nondisjunction, we examined the association between these two well established risk factors for chromosome 21 nondisjunction. In our approach, short ...

Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal development and are thought to have long-lasting consequences on adult health. Epidemiological and e...

1. The objective of the study was to explore the genetic architecture of blood oxygen saturation (SaO) (an indicator trait, negatively correlated with ascites susceptibility), body weight (Weight) and fleshing score (Flesh, a measure of breast conformation) for 4 meat-type chicken lines reared in commercial conditions. 2. Genetic components, including heritabilities and genetic correlations, we...

Rationale/ statement of the problem: Substantial evidence suggests conditions in intrauterine life may play a critical role in subsequent health and disease susceptibility related outcomes (i.e., the concept of fetal or developmental programming of health and disease). The elucidation of biological mechanisms underlying these effects is an area of active investigation. We suggest that telomere ...

F ollowing on the seminal observations of Barker and associates (1), maternal hormonal and nutrient environment has been systematically implicated in effects on the developing fetus that ultimately influence susceptibility to a wide range of metabolic, neurodevelopmental, and psychiatric diseases in adulthood (2, 3). There is a growing appreciation that perturbations in the maternal environment...

Tuberculosis (TB) cellular immune responses were examined in the breast milk of human immunodeficiency virus infected mothers using the T-SPOT. TB interferon-gamma release assay (IGRA). Positive TB interferon-gamma (IFN-γ) responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breast milk and blood assays, TB IFN-γ responses were higher in breast milk than...