Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic lymphocytic leukemia (B-CLL). We screened the mRNA expression of tumor-associated antigens (TAAs) from the literature (fibromodulin, survivin, OFA-iLRP, BAGE, G250, MAGE1, PRAME, proteinase, syntaxin, hTERT, WT-1) and TAAs defined previously by serological analysis of cDNA expression libraries from leukemic ce...

The question, how true concurrency differs from interleaving, has been studied intensively, beginning with the works of Mazurkiewicz [Maz], Milner [Mil], Pratt [Pra] and many others. The Mazurkiewicz trace theory requests for specifying the dependency relation, which makes such difference explicit. If in some state the sequences ab and ba are executable, then if a and b are independent, then bo...

KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target for anticancer drugs. In this study we report a new delivery strategy for a G4-decoy oligonucleotide that sequesters MAZ, a transcription factor essential for KRAS transcription. It is based on the use of palmitoyl-oleyl-phosphatidylcholine...

In the present article we give geometric generalizations of the estimates from Chapters 5,6,7 from [4], while extending their sharpness to new cases.

1. Greenwald MJ, Weiss A, Oesterle CS, Friendly DS. Traumatic retinoschisis in battered babies. Ophthalmology. 1986;93:618-625. 2. Massicotte SJ, Folberg R, Torczynski E, Gilliland MGF, Luckenbach MW. Vitreoretinal traction and perimacular retinal folds in the eyes of deliberately traumatized children. Ophthalmology. 1991;98:1124-1127. 3. Lantz PE, Sinal SH, Stanton CA, Weaver RG Jr. Perimacula...

Automatic beat tracking is challenging task, especially for audio music with time-varying meters. This study proposes a dynamic programming approach with positional weighting window to handle beat tracking with time-varying meters. In particular, the tempo curve is the reference to obtain correct beat positions. The weighting window is used to adapt bandwidth of tempo which reciprocal represent...

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