Pharmacological evidence indicates that the basolateral nucleus of the amygdala (BLA) is involved in the mediation of inhibitory avoidance but not of escape behavior in the elevated T-maze test. These defensive responses have been associated with generalized anxiety disorder (GAD) and panic disorder, respectively. In the present study, we determined whether the BLA plays a differential role in ...

In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta(1-42)- (Aβ(1-42)-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ(1-42) and then treated with SCH (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a reference drug (0....

Nepeta L. (Lamiaceae) species are belonging to aromatic and medicinal plants. Many biological activities of have been reported. In this study, memory-enhancing nuda ssp. essential oil was aimed be evaluated in laboratory rats treated with scopolamine. GC-MS/GC-FID system used identify composition. Memory performances the were tested using Y-maze radial-arm maze. Acetylcholinesterase enzyme acti...

The effect of a new conjugate hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals chronic cerebrovascular insufficiency (CCI) was studied. CCI modeled rats by stenosis thelumen the carotid arteries 60 %. 40 days after operation, groups were formed test compound administered for 14 days. Citicoline used as reference drug, saline placebo. After trea...

The study investigated the effects of ‘low doses’ of monosodium glutamate (MSG) on hippocampal-related (spontaneous working-memory, memory-recall and anxiety) behaviours, and hippocampal glutamate/glutamine levels. A two-trial Y-maze test and 8-arm radial-arm maze spontaneous working-memory test were used to assess the effects of acute and repeated administration of MSG, on novel-arm choice on ...

This study examined behavioral effects mediated by NMDA (N-methyl-D-aspartic acid) receptors in 12-week streptozotocin (STZ)-induced diabetic rats. Effects of an NMDA receptor agonist on behavior in the open field test, passive avoidance test and T-maze were examined in control groups of rats and in rats with diabetes mellitus (DM). We have used 116 rats for experiments. Experimental type I dia...

Reality is one of the important characteristics of computer graphics and Virtual Reality. We focused on one element of Reality called ‘Interaction’. We investigated whether continuity of image-movement along with operation on a virtual maze has any effect on spatial cognition or not. Subjects did the task of filling walls of a maze on answer form during exploration of the virtual maze by using ...

The influence of the blockade of group I metabotropic glutamate receptors (I mGluRs) by AIDA on some behavioral effects of rats pretreated with baclofen, an agonist of GABA-B receptor, was investigated using behavioral tests: the open field, the passive avoidance response and the elevated "plus" maze. Baclofen, applied intraperitoneally (ip) at a dose of 0.25 mg/kg, increased the number of cros...

BACKGROUND Administration of the N-methyl-D-aspartate (NMDA) antagonist ketamine during the perinatal period can produce a variety of behavioral and neuroanatomical changes. Our laboratory has reported reliable changes in learning and memory following a single dose of ketamine administered late in gestation. However, the nature of the drug-induced changes depends on the point during embryonic d...

It has previously been suggested that the activity in sensory regions of the brain can be modulated by attentional mechanisms during parallel cognitive processing. To investigate whether such attention-related modulations are present in the processing of pain, the regional cerebral blood ̄ow was measured using [O]butanol and positron emission tomography in conditions involving both pain and par...