Quinoxaline-2-carboxylic acid (QXC) and 3-hydroxyquinaldic acid (HQA) feature in quinomycin family and confer anticancer activity. In light of the significant potency against cancer, the biosynthetic gene clusters have been reported from many different Streptomyces strains, and the biosynthetic pathway were proposed mainly based on the in vivo feeding experiment with isotope labeled putative in...

A new and direct colorimetric method has been established for the determination of catecholamine (methyldopa, MD) in both pure form pharmaceutical formulations. The is based on oxidative coupling reaction MD with 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) potassium ferricyanide at pH 10.4 aqueous medium to an orange product that a maximum absorption 460 nm. Beer's l...

Abstract Green analytical chemistry is one of the newest trends in nowadays targeting concept green laboratory practices on chemists and environment. In this text, are proposed work for determination sofosbuvir (SF) velpatasvir (VP) their pharmaceutical formulation. The analysis SF a binary mixture with VP represents an challenge due to complete overlapping UV spectrum by that VP. Therefore, di...

Two simple and sensitive methods have been developed for the estimation of rosvastatin in bulk and in pharmaceutical dosage forms. Method A is based on the oxidative coupling of rosvastatin with MBTH in presence of oxidant cerric ammonium sulphate and the λmax of the colored species was found to be 658 nm. Method B is based on the formation of co-ordination complex between rosvastatin and cobal...

The antitumor agent thiocoraline is a nonribosomally biosynthesized bisintercalator natural product, which contains in its peptidic backbone two S-methylated l-cysteine residues. S-Methylation occurs very rarely in nature, and is observed extremely rarely in nonribosomal peptide scaffolds. We have proposed that during thiocoraline biosynthesis, TioN, a stand-alone adenylation domain interrupted...