K. Keahey T. Fredian Q. Peng D. P. Schissel M. Thompson I. Foster 5 M. Greenwald D. McCune 1 Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL 60439 2Plasma Science and Fusion Center, MIT, Cambridge, MA 02139 3General Atomics, P.O. Box 85608, San Diego, California, 92186-5608 4Lawrence Berkeley National Laboratory, Berkeley, CA 94720 5 Department of Computer Sc...

The presented clinical case describes orphan disease known as MAS with manifested symptoms of precocious puberty, recurrent ovarian cysts, fibrous dysplasia, café-au-lait skin pigmentation and abnormal cardiac conduction. pathogenesis is based on the GNAS gene mutation that cause hyperactivation glycoprotein hormone receptors hypersecretion. There are genetic tests confirm diagnosis, however, g...

McCune Albright syndrome is diagnosed by a constellation of Café-au-lait spots, multiostosis fibrous dysplasia and precocious puberty. Other endocrine dysfunctions which are often associated are growth hormone excess, hyperthyroidism, Cushings syndrome, hyperprolactinemia and phosphate wasting. Its prevalence is 1:100000–1:1000000 in different ethnicity [1]. It is a rare cause of precocious pub...

Fibrous dysplasia is a benign bone lesion of unknown etiology. Bone involvement usually is solitary (monostotic). Multiple forms (polyostotic) associated with extra skeletal symptoms, particularly cutaneous pigmentation, endocrine dysfunction and precocious puberty is called McCune-Albright syndrome (MAS). We report the case of a 40-year-old man who presented with left mandibular body expansion...

Cyprostate acetate (CPA) has been used in the treatment of hyper sexuality, which is considered as carcinogenic agent and its use has been prohibited for children. We presented young patient having hepatocellular carcinoma (HCC) with medication history of CPA during childhood, which arose from normal background liver without virus infections and other causes of liver dysfunction. The patient ha...