The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). Specific biomarkers are needed to improve diagnoses and therapeutic approaches in this dual pathology. Platelet biomarkers [5-HT2A receptor and imidazoline r...

OBJECTIVES The objectives of this study were to provide estimates of the prevalence and strength of association between major depression and chronic pain in a primary care population and to examine the clinical burden associated with the two conditions, singly and together. METHODS A random sample of Kaiser Permanente patients who visited a primary care clinic was mailed a questionnaire asses...

This study examined whether development of two forms of cognitive control (proactive and reactive) between early and midadolescence was associated with the onset of major depressive disorder (MDD) during the same period and if it prospectively predicted MDD onset between mid- and late adolescence. Adolescents (N = 165) completed 3 waves of assessments, at 12 (T1), 16 (T2), and 18 (T3) years of ...

BACKGROUND Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) frequently co-occur after traumatic experiences and share neurocognitive disturbances in verbal memory and executive functioning. However, few attempts have been made to systematically assess the role of a comorbid MDD diagnosis in neuropsychological studies in PTSD. OBJECTIVE The purpose of the current study ...

objective: suicide is one of the most important early causes of death in psychotic patients. the main object of this research was to determine the relationship between positive and negative symptoms of schizophrenia and psychotic major depressive disorder (mdd) with suicidal history and risk. methods: sixty five patients with schizophrenia compared to 65 patients with psychotic mdd in a cross s...

Twenty-three adolescents hospitalized on an inpatient psychiatric unit underwent a dexamethasone suppression test (DST) and were diagnosed as having major depressive disorder by interviewers blind to the DST results. These patients were divided into four categories according to whether they had major depressive disorders, endogenous ( MDDe ) or nonendogenous (MDD), and whether they were nonsupp...

by KUMARASWAMY BUDUR, MD Objective: Major depressive disorder (MDD) is associated with sleep disturbances. An electroencephalographic (EEG) pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with MDD. The treatment-resistant symptoms in MDD, non-restorative sleep and fatigue, are associated with alpha-delta sleep. The objective of this study is ...

BACKGROUND To examine cross-national patterns and correlates of lifetime and 12-month comorbid DSM-IV anxiety disorders among people with lifetime and 12-month DSM-IV major depressive disorder (MDD). METHOD Nationally or regionally representative epidemiological interviews were administered to 74 045 adults in 27 surveys across 24 countries in the WHO World Mental Health (WMH) Surveys. DSM-IV...

The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on gut microbiota MDD are inconsistent, data MDD's effects sleep lacking. This study aimed to analyze composition quality patients with MDD. We performed 16S rRNA sequencing stool samples from 36 45 healthy controls (HC). Sleep was assesse...

Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) have identified few susceptibility variants or genes that are robustly associated with MDD. Standard single-SNP (single nucleotide polymorphism)-based GWAS analysis typically has limited p...