Threshold selection is a critical step in using binary change detection methods. The threshold determines the accuracy of change detection results but is highly subjective and scene-dependent, depending on the familiarity with the study area and the analyst’s skill. Nearest neighbor classification is a nonparametric classifier, which was applied to remove the threshold. In order to find the mos...

Physical disfigurement and functional impairments associated with facial trauma are a challenge to a prosthodontist, because even novel sophisticated surgical reconstructive techniques fail to provide adequate support for dental resection prosthesis. Therefore, different endosseous implants are often used as prosthesis-supporting elements. Manufacturers of dental implants have recently presente...

BACKGROUND Many factors contribute to the high variability of doses delivered to the lungs of patients using metered dose inhalers (MDIs). Relatively little attention has been paid to the contribution to this variability of the way in which the MDI is handled before the inhalation manoeuvre. Instruction leaflets often recommend procedures at odds with those used for in vitro testing of the devi...

OBJECTIVE Medication adherence is associated with the treatment outcomes. The reported consequences of non-adherence for patients with depressive disorders include chronification, poor psychosocial outcomes and increased suicide rates. The aim of this study is to determine whether insight is directly associated with the medication-taking adherence of patients with depressive disorders. In addit...

BACKGROUND The percentage of patients inhaling their medication effectively varies widely, according to methods of assessment and inhalers used. This study was carried out to assess differences among four types of inhalers using inhaler-specific checklists. METHODS Inhalation technique was evaluated in adult patients with chronic obstructive pulmonary disease (COPD). Inhalers investigated wer...

BACKGROUND One-piece narrow diameter implants (NDIs) have been recommended as "Single-tooth replacements in the anterior zones, single posterior, multiple-unit fixed dental prosthesis (FDP), edentulous jaws to be rehabilitated with FDP, and edentulous jaws rehabilitation with overdentures in situations with reduced mesiodistal space or reduced ridge width." (ITI consensus 2013). Since NDIs can ...

Dry powder inhalers (DPIs), opposed to the traditional pre-metered dose inhalers (MDIs), prove to be more advantageous in delivering the desired dosage of medication to the targeted site. Now, engineers are designing better DPIs and new carrier particles that have better characteristics for drug delivery.

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1341 possibility of adverse side effects or children have difficulty using metered-dose inhalers (MDIs). New therapeutic options are available and with aggressive, appropriate therapy, physicians can prescribe an asthma management regimen to ameliorate symptoms, control disease and allow normal activity even in children as young as one to two years.

Abbreviations used in this paper: ANOVA, analysis of variance; ChrgA, chromogranin A; CM, membrane capacitance; Cpx, complexin; dko, double ko; EB, exocytotic burst; ko, knockout; MDis, median distance; NMJ, neuromuscular junction; NP, nitrophenyl; rms, root–mean–square; RRP, readily releasable pool; SR, sustained rate; SRP, slowly releasable pool; SybII, synaptobrevinII; Syt, synaptotagmin; wt...