Scientific knowledge is constantly expanding, and needs are changing; therefore, efforts must be made to adapt the treatment of leprosy and the manner in which it is implemented to the newly identified needs. Because an effective vaccine against leprosy remains to be identified, multidrug therapy (MDT) is the only tool available for leprosy control. At present, therefore, the priority is to mak...

Maggot debridement therapy (MDT) is effective for treating intractable wounds, but its precise molecular mechanism, including the association between MDT and growth factors, remains unknown. We administered MDT to nine patients (66.3 ± 11.8 yr, 5 male and 4 female) with intractable wounds of lower extremities because they did not respond to conventional therapies. Significant increases of hepat...

Maggot debridement therapy (MDT) has become more and more common in the treatment of chronic wounds. In the last decade alone, more than 100 papers were published on this subject. MDT is used to aid in removing necrotic tissue from a wound, thus resulting in a reduction of amputations. The limb salvage rate is reported as 50% after use of MDT. This article presents an overview of the history of...

This paper illustrates the characteristics of the multiple decision-tree (MDT) model, which we proposed in a previous work. MDT is an extension of the decision-tree model and is proposed for its robustness against input uncertainty. We present simulation results to show that the MDT model is task-independent and outperforms both the conventional decision-tree model and the majority model agains...

UNLABELLED Recently antimicrobials of the fluoroquinolone class (pefloxacin and ofloxacin) were found far more effective against Mycobacterium leprae in studies with both mice and patients than dapsone and clofazimine. As multicentre trial participants, we evaluated the therapeutic efficacy, in terms of rate of relapse, of two new multidrug regimens containing ofloxacin, comparing them to 1 yea...

We read with interest the recent article by Blazeby et al. [1], which described the implementation of decisions made by a multidisciplinary team (MDT). The study evaluated 273 decisions about patient management made at a central MDT meeting in Bristol, which assessed cases of patients with upper gastrointestinal cancer, including cases from several surrounding satellite hospitals. They found th...

BACKGROUND AND PURPOSE Integrated care pathways (ICP) may not reduce disability, institutionalization, or duration of hospitalization compared with conventional multidisciplinary team (MDT) care in organized stroke rehabilitation. Their potential to improve patient heath status or satisfaction with care is not known. METHODS A comparison of quality of life, caregiver strain, and patient/careg...

BACKGROUND Evidence from recent literature shows that protocol-directed extubation is a useful approach to liberate patients from mechanical ventilation (MV). However, research evidence does not necessarily provide guidance on how to implement changes in individual intensive care units (ICUs). We conducted the present study to determine whether such an evidence-based strategy can be implemented...

AIM To evaluate the incidence of and risk factors for ocular complications in multibacillary (MB) leprosy patients following completion of 2 year, fixed duration, multidrug therapy (MDT). METHODS Biannual eye examinations were conducted prospectively on a cohort of MB patients who had completed MDT and followed up for 5 years. The incidence of ocular pathology was calculated as the number of ...

PURPOSE This study was conducted to explore the process and operation of a cancer multidisciplinary team (MDT) after the reimbursement decision in Korea, and to identify ways to overcome the major barriers to effective and sustainable MDTs. MATERIALS AND METHODS Approximately 1,000 cancer specialists, including medical oncologists, surgical oncologists, radiation oncologists, pathologists, an...