Oxaliplatin (OXL) is a third-generation chemotherapeutic agent commonly used to treat metastatic digestive tumors; however, one of the main limiting complications of OXL is neuropathic pain. In this study, the underlying mechanisms responsible for OXL evoked-neuropathic pain were examined. Using a rat model, the results demonstrated that intraperitoneal (i.p.) injection of OXL significantly inc...

in this study, a one-dimensional model called dyresm was used to simulate the thermal structure and artificial destratification of 15-khordad reservoir over a period of one year. the simulation showed that the reservoir is warm monomictic and is stratified during 210 days of the simulation year. the model reproduced the temperature of the meta- and hypolimnion very close to the observed data, b...

the full annealing aa6061 aluminum alloy was subjected to severe plastic deformationvia the combination of equal channel angular pressing (ecap) and cold rolling (cr) in order torefine its microstructure and to improve its mechanical properties. according to the results of hotand cold tensile tests, the combination of ecap and cr significantly affected the final strengthand ductility of studied...

Sensory hair cells in auditory and vestibular organs rely on active mechanisms to achieve high sensitivity and frequency selectivity. Recent experimental studies have documented self-sustained oscillations in hair cells of lower vertebrates on two distinct levels. First, the hair bundle can undergo spontaneous mechanical oscillations. Second, somatic electric voltage oscillations across the bas...

Abstract Mechanical sensitivities (such as friction and impact sensitivity) are the most important evaluation index to characterize risk of energetic materials (EMs), they common stimulus during preparation, transportation usage EMs. Recently, carbon nanomaterials (CNMs) have been found be effective in reducing mechanical EMs with small amount addition. This review covers updated researches des...

Buckling, first introduced by Euler in 1744 [Euler L (1744) Opera Omnia I 24:231], a sudden mechanical sideways deflection of a structural member under compressive stress, represents a bifurcation in the solution to the equations of static equilibrium. Although it has been investigated in diverse research areas, such a common nonlinear phenomenon may be useful to devise a unique mechanical sens...

A single bout of exercise is associated with postexercise hypotension, transient decreases in autonomic function, and changes in baroreflex sensitivity. The baroreflex is less sensitive to falling blood pressure than to rising blood pressure; we characterized the cardiac baroreflex in terms of hysteresis and its mechanical and neural components. We hypothesized that hysteresis would be exacerba...