Abstract Over the past decade, T cell immunotherapy has changed face of cancer treatment, providing robust treatment options for several previously intractable cancers. Unfortunately, many epithelial tumors with high mortality rates respond poorly to immunotherapy, and an understanding key impediments is urgently required. Cancer-associated fibroblasts (CAFs) comprise most frequent nonneoplasti...

dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...

Objective(s) Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. Materials and Methods Addiction was induced by progressive incremental doses of morphine over 7 days. Behavioral si...

background: breast cancer is the most common cancer in women worldwide. recently, natural remedies such as naringenin (nar) - a kind of flavonoids which can be found in grapefruits, oranges, and tomatoes - seem to be interesting. they play a useful role in treatment and chemoprevention because of having pleiotropic molecular mechanisms of action on breast cancer cells. methods: we performed a p...

the aim of current study was to determine women´s maternal asthma in pregnancy, delivery and birthl outcomes. using a retrospective cohort design, data of 580 pregnant women were gathered form a large teaching hospital in tehran, iran. the medical records of pregnant women who had attended this hospital between 2009 and 2011 were assessed. data of delivery and birth outcomes were gathered by ob...