Present paper deals with the development of a Mechanistic-Empirical model strain-based design perpetual road pavement using Odemark's principle. The bituminous which can withstand minimum traffic 300 msa has been classified as in this paper. considered three-layered system top layer mix followed by unbound granular materials rest on soil subgrade. constituent thickness determined limiting radia...

We are entering a period of rapid and pronounced environmental change. Understanding how this change will in! uence soil communities is essential for accurate prediction of future climate, biogeochemical cycles, and human well-being. Such reliable prediction is the fundamental test of scienti" c understanding (i.e. can we use knowledge of underlying mechanisms to predict accurately how phenomen...

In many current state-of-the-art bridge management systems, Markov models are used for both the prediction of deterioration and the determination of optimal intervention strategies. Although transition probabilities of Markov models are generally estimated using inspection data, it is not uncommon that there are situations where there are inadequate data available to estimate the transition pro...

When neuroscientists explain the biological basis of a phenomenon of interest, they usually try to identify the parts of a system that seem do the relevant job, and propose a model of how those parts interact to produce the phenomenon. This mechanistic framework of explanation is widely used and has been investigated from a philosophical point of view by different authors. In his target article...

The mitogen activated protein kinase (MAPK) cascade is a three-tiered phosphorylation cascade that is ubiquitously expressed among eukaryotic cells. Its primary function is to propagate signals from cell surface receptors to various cytosolic and nuclear targets. Recent studies have demonstrated that the MAPK cascade exhibits an all-or-none response to graded stimuli. This study quantitatively ...

Background: As a transportation infrastructure that connects one area to another, roads have an essential role in economic and social growth, together with establishing location may improve the quality of life surrounding community. For this reason, it is necessary perform road maintenance when structural or functional capacity inadequate, which by overlaying road. Objective: The main objective...