Geometry of the heart adapts to mechanical load, imposed by pressures and volumes of the cavities. We regarded preservation of cardiac geometry as a homeostatic control system. The control loop was simulated by a chain of models, starting with geometry of the cardiac walls, sequentially simulating circulation hemodynamics, myofiber stress and strain in the walls, transfer of mechano-sensed sign...

Tactile-foraging ducks are specialist birds known for their touch-dependent feeding behavior. They use dabbling, straining, and filtering to find edible matter in murky water, relying on the sense of touch in their bill. Here, we present the molecular characterization of embryonic duck bill, which we show contains a high density of mechanosensory corpuscles innervated by functional rapidly adap...

OBJECTIVE To evaluate the effect of GONB, with or without trigger point injection (TPI), on dynamic mechanical (brush) allodynia (BA) and on head pain in migraine. Background.-Patients with migraine often have cutaneous allodynia that is related to sensitization of central pain neurons. Greater occipital nerve block (GONB) is an effective treatment for migraine headache; however, its effect on ...

In the past years, a number cardiac electromechanics models have been developed to better understand the excitation-contraction behavior of the heart. However, there is no agreement on whether inertial forces play a role in this system. In this study, we assess the influence of mass in electromechanical simulations, using a fully coupled finite element model. We include the effect of mechano-el...

From accumulating studies of hexameric helicases, a mechano-chemical coupling mechanism has emerged which postulates that the nucleoside triphosphate (NTP) hydrolysis is sequentially coordinated together with the binding and translocation of nucleic acid substrate. Various mechano-chemical models have been proposed for different hexameric helicases with no consensus for a common mechanism. To e...

The arterial baroreflex system may be divided into the mechano-neural arc from pressure input to sympathetic nerve activity (SNA) and the neuro-mechanical arc from SNA to arterial pressure (AP). We explored a new strategy to estimate total baroreflex gain (Gbaro) using an equilibrium diagram between the mechano-neural and neuromechanical arcs. In 8 anesthetized rabbits, a neck suction procedure...

BACKGROUND The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-] and thus the magnitude and polarity of GABAA receptor responses in neurons. TRPV1 receptors transduce diverse chemical and natural stimuli in nocice...

In brief: Chondrocyte-specific ablation of the mechano-sensory Piezo1 results in substantially impaired formation secondary spongiosa during endochondral bone formation. The study explores this unexpected finding and show that mechano-sensing growth plate chondrocytes directly regulates trabeculae spongiosa.

Cutaneous allodynia is a common feature accompanying migraine attacks and considered a clinical marker for central sensitization. In a longitudinal study, we wanted to investigate if allodynia in migraine patients is a predictor of increasing frequency of migraine days. We included 3029 well-defined, web-based migraine patients (86% female, mean age 42.8 ± 11.4 years, 61% migraine without aura)...

Crayfish (A. astacus) stretch receptors are an example of invertebrate muscle stretch receptors. They show strong homology to mammalian muscle spindles and bi-polar neurons in D. melanogaster, which are typical, non-ciliated, multi-dendritic, afferent neurons. Such receptors are observed in many species and perform an important sensory role. However, they are poorly characterised. A previous bi...