Introduction Alcohol dependence syndrome is a major public health issue globally and is responsible for significant morbidity and mortality. The total dose of alcohol consumed has been linked to liver diseases, pancreatitis, and other alcohol-related medical consequences. However, this has not been studied in relation to severity of dependence; although it is well known that alcohol causes neur...

psoriasis is an autoimmune and recurrent chronic inflammatory skin disease. about 1-3% of the world wide populations are affected. the characteristic features are hyperprolifration of keratinocytes leading to redness, thickening and scaling of epidermis followed with itching and appearance of the lesions which in most cases bother the patients medically and psychologically. psoriasis is symptom...

A new health impact index, excess cost, is advocated for identifying jobs in need of further study regarding ergonomic problems. The excess cost index is compared with incidence rate, excess count, and severity rate indices in terms of concept and appropriateness to the purpose. The four indices are illustrated with data regarding medical leave from an automobile assembly plant and evaluated in...

Although Gamblers Anonymous (GA) is a popular intervention for gamblers, many attendees later present for professional treatment. This study evaluated gambling and psychosocial problems in individuals seeking professional treatment for gambling and compared those with and without a history of GA attendance. At intake to treatment, 342 pathological gamblers completed the Addiction Severity Index...

We investigated the differential influence of family dysfunction on alcohol and methamphetamine dependence in Japan using the Addiction Severity Index (ASI), a useful instrument that multilaterally measures the severity of substance dependence. The participants in this study were 321 male patients with alcohol dependence and 68 male patients with methamphetamine dependence. We conducted semi-st...

AIM To examine the change in alcohol use parameters following a brief intervention (BI) based on the FRAMES protocol, compared to simple advice (SA), in a community setting in North India. METHOD Ninety male subjects, 20-45 years old, with an AUDIT score between 8 and 24, consented to participate in this study. They were recruited from an earlier study on treatment, non-seeking, and allocated...

BACKGROUND Asthma exacerbations are frequent in patients with severe disease. This report describes results from two retrospective cohort studies describing exacerbation frequency and risk, emergency department (ED)/hospital re-admissions, and asthma-related costs by asthma severity in the US and UK. METHODS Patients with asthma in the US-based Clinformatics™ DataMart Multiplan IMPACT (2010-2...

PURPOSE To establish the genotype-phenotype correlations of various CYP1B1 (human cytochrome P450) mutations in patients in India with primary congenital glaucoma (PCG). METHODS The study cohort comprised 146 patients with PCG from 138 pedigrees. Patients were analyzed for six distinct CYP1B1 mutations by sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-R...