Case A: 42 year old female patient without asthma or polyposis nasi presented with palmar and plantar pruritus, urticaria, facial angioedema and dyspnea on two occasions: 2 and 4 hours after the intake of two structurally independent NSAIDs (diclofenac 75 mg, mefenamic acid 500 mg). In both instances, pantoprazole, a proton pump inhibitor (PPI), was prescribed for gastric protection. A non-alle...

The clinical, radiological, and histological features of two patients with severe intestinal damage induced by mefenamic acid and mimicking coeliac disease are described. Symptoms rapidly reverted on withdrawal of the drug, and in one case, did not relapse during treatment with other non-steroidal anti-inflammatory drugs.

Background and aim: Melissa officinalis was traditionally used for pain relief and treatment of some diseases. The aim of the study was to compare the effect of mefenamic acid and Melissa officinalis (Melissa) on pain management in primary dysmenorrhea. Methods: In this clinical trial, fortythree eligible women with moderate to severe primary dysmenorrhea were randomly allocated into the Meliss...

Organotin(IV) compounds have gained significant interest in both the chemical and pharmaceutical industry. This research concentrates on synthesis of di tri-organotin complexes with mefenamic acid characterized different techniques such as elemental analysis, FTIR, proton carbon NMR. The anti-oxidant properties were assessed using 1,1-diphenyl-2-picrylhydrazyl, DPPH CUPRAC Method . complexes' s...

CONTEXT Seizures during intoxications with pharmaceuticals are a well-known complication. However, only a few studies report on drugs commonly involved and calculate the seizure potential of these drugs. OBJECTIVES To identify the pharmaceutical drugs most commonly associated with seizures after single-agent overdose, the seizure potential of these pharmaceuticals, the age-distribution of the...

Analysis of acetaminophen, mefenamic acid, sibutramine hydrochloride, and sildenafil citrateEva Susanty Simaremare, Rizka Agustine Susilowati, Yeyen Dwi Astuti, Rusadi Hermawan, Elsye Gunawan, Rani Dewi Pratiwi, Rusnaeni

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of mild-to-moderate pain. Mefenamic acid belongs to the Biopharmaceutical Classification System (BCS) class II drug which has lower water solubility but high permeability. There are two different compendial methods available for dissolution tests of mefenamic acid solid dosage forms, i.e. meth...