Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte – melanocyte unit, or as with the ...

Like all primary cells in vitro, normal human melanocytes exhibit a physiologic decay in proliferative potential as it transitions to a growth-arrested state. The underlying transcriptional program(s) that regulate this phenotypic change is largely unknown. To identify molecular determinants of this process, we performed a Bayesian-based dynamic gene expression analysis on primary melanocytes u...

INTRODUCTION Occurence of vitiligo lesions is caused by the destruction of melanocytes in a ected skin and therefore by the re- duction of pigment melanin content. Questions remain about the presence of residual melanocytes in the depigmented skin and optimal methods of their identi cation. METHODS Skin biopsy samples from 16 patients with non-segmental vitiligo and from 10 healthy volunteers...

Vitiligo is a skin disease characterized by the destruction of epidermal melanocytes. As main constituent cells in epidermis, keratinocytes facilitate melanocytes loss under oxidative stress inducing melanocyte death or recruiting CD8+ T to destroy However, effect exosomes from on survival and activity CD8+T unknown. Exosomes (Exo.T) culture media H2O2-treated human (HaCaT) were extracted using...

Annotation. Malignant and benign skin neoplasms are multifactorial diseases, the development of which is perhaps most related to environmental factors. The search for constitutional markers predicting occurrence these cancers has become one promising areas research in field oncology. aim study was establish features transverse body sizes Ukrainian men with nevi. In (aged 22-35 years) nevi (mela...

The biological and enzymic behaViDr of embryonic melanocytes and their cellular interaction in differentiating follicular and epidermal structures after leaving their dermal environment through the penetration of the dermalepidermal junction has not been significantly studied, although their neural crest origin (1) and developmental process within the dermis including their epidermal entry (2) ...

A cut was made on the middorsal skin of mice of various ages of strain C57BL/0J using fine iridectomy scissors. Specimens from the wounded skins were fixed at various days after wounding and were subjected to the dopa reaction and to the combined dopa-premelanin reaction. When the dorsal skins of 1.5-day-old mice were wounded, the melanocyte population positive to the dopa reaction as well as t...

Utilization of adult stem cells in regenerative therapies may require a thorough understanding of the mechanisms that establish, recruit and renew the stem cell, promote the differentiation of its daughters, or how the stem cell is repressed by its target tissue. Regeneration of melanocytes in the regenerating zebrafish caudal fin, or following larval melanocyte-specific ablation, or recruitmen...

Melanocyte regeneration in epidermis (e.g., vitiligo) and matrix of hair follicle graying hair) is quite dependent on the migration melanocyte precursors located follicle. We have demonstrated that casein kinase (CK) 1 ablation keratinocytes increases eumelanin production epidermal numbers. Here we further evaluate effect CK1 inhibition first established Fusion Red-labelled-melanocyte reporter ...

Like all primary cells in vitro, normal human melanocytes exhibit a physiologic decay in proliferative potential as it transitions to a growth-arrested state. The underlying transcriptional program(s) that regulate this phenotypic change is largely unknown. To identify molecular determinants of this process, we performed a Bayesian-based dynamic gene expression analysis on primary melanocytes u...