BACKGROUND Patients with aspirin-sensitive respiratory and skin diseases experience cross reactions to all nonsteroidal anti-inflammatory drugs (NSAIDs) which inhibit cyclooxigenase (COX) enzymes. The need to identify an alternative drug that is safe and reliable is a common problem in clinical practice. OBJECTIVE The aim of this study was to test the tolerability of meloxicam in NSAID-sensit...

This multicentre, randomized, open controlled study compared the local and overall tolerability of i.m. meloxicam with i.m. piroxicam in 211 patients with rheumatoid arthritis (RA) (n = 95) or osteoarthritis (OA) (n = 116). Of these, 210 patients were randomized (2:1) to receive meloxicam 15 mg (n = 144) or piroxicam 20 mg (n = 66) for 7 days. Local tolerability of meloxicam was significantly b...

Meloxicam is a cyclo-oxygenase-2 (COX-2) preferential non-steroidal anti-inflammatory drug with very effective analgesic and anti-inflammatory effects in swine. Previous reports in piglets have demonstrated that meloxicam also inhibits COX-1 and reduces production of thromboxane significantly. We use preinjury analgesia in our immature swine (3–5-day-old piglets) model of brain injury using rap...

BACKGROUND Because the recurrence rate of hepatocellular carcinoma (HCC) is high, even after curative treatments such as hepatic resection and microwave ablation, chemopreventive agents that can effectively suppress HCC recurrence are required. Cyclooxygenase-2 (Cox-2) was recently found to be overexpressed in HCC. Therefore, Cox-2 inhibitors may offer a chemopreventive therapy for HCC. This ra...

The improvement of electrochemical detection of meloxicam is presented by modification of a glassy carbon electrode with anionic layer of cysteic acid providing electrostatic accumulation of the analyte onto the electrode surface. The modification formed by electrochemical oxidation of L-cysteine was performed by cycling potential in cysteine solution. The anodic peak current obtained at + 1.08...

BACKGROUND Castration is one of the most common procedures performed on beef and dairy cattle. The objective of the study was to determine the efficacy of meloxicam oral suspension in reducing pain and inflammation in calves following band or surgical castration. METHODS Two identical trials with the exception of the method of castration (Band Castration Study 1 and Surgical Castration Study ...

the purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. seventy male wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (s) (control group, 1.0 ml kg-1), morphine (mo) (4.0 mg kg-1), tramadol (tr) (12.5 mg kg-1), meloxicam (ml) (1.0 mg kg-1), tramadol- morphin...

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX), the enzyme responsible for the first step in synthesis of various prostaglandins (PGs) from arachidonic acid. COX exists as two isoforms, COX-1, which is constitutively present in almost all cells and produces PGs concerned with protection of the gastric mucosa and kidney functions, and COX-2, which ...

OBJECTIVE To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. DESIGN Randomized controlled study. ANIMALS 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to 10.4 lb]). PROCEDURE Cats received 1 of 5 treatments at the time ...

Meloxicam, a non-steroidal anti-Inflammatory drug has been registered in Pakistan as a safe substitute of diclofenac sodium which was banned for veterinary use, due to its relay toxicity associated with the catastrophic decline in vulture population of the Indian subcontinent. In Pakistan, Injection is the only dosage form registered for veterinary purposes whereas Boehringer Ingelheim are lice...