Curcumin is coming from the Curcuma longa which gives golden color and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using di...

Direct microjoining using Yttrium-Aluminium-Garnet (YAG) laser beams of copper wire and a plate or substrate board was carried out. The control of the behavior of the molten wire was extremely important to prevent joining defects such as evaporation or constriction of the wire. Both the contact angle between the wire and the plate and the distance from the tip of the wire to the laser irradiati...

The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and v...

Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...

Bast fibers from stems of kenaf (Hibiscus cannabinus, L.), a warm-season tropical herbaceous annual plant, were dispersed into poly-L-lactide (PLLA) matrix by melt-mixing followed by compression molding. Low fiber fractions (1–5%) were investigated. The composites showed a slight lowering of thermal stability when evaluated by thermogravimentric analysis. X-ray diffraction and differential scan...

The aim of this study was to produce isotactic polypropylene based composites filled with waste thermosetting bulk moulded composite (BMC). The influence of BMC waste addition (5, 10, 20 wt%) on composites structure and properties was investigated. Moreover, additional studies of chemical treatment of the filler were prepared. Modification of BMC waste by calcium stearate (CaSt) powder allows t...

a novel mixing approach for achieving a good dispersion of multi-walled carbon nanotubes (mwcnts) in ethylene- propylene diene monomer (epdm) matrix has been investigated. in this approach epdm was modified with vinyltrimethoxysilane (vtms) during melt mixing. in addition the effect of mwcnt concentration on mechanical and rheological properties of modified epdm has been studied. the formulated...

The use of hot-melt extrusion for preparing homogeneous API-excipient mixtures is studied for miconazole-PEG-g-PVA [poly(ethylene glycol)-poly(vinyl alcohol) graft copolymer] solid dispersions with a 5 cm(3) table-top, twin-screw corotating microcompounder (DSM Xplore). Phase behavior of PEG-g-PVA, miscibility of miconazole in PEG-g-PVA and the partitioning of miconazole between PEG and PVA amo...