The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and screw speed. During the extrusion process,...

In this paper the relationship between molecular structure and behavior of the LDPE melt is discussed from a scaling perspective on the bases of results from GPC-MALLS analysis. Long chain branches introduce a characteristic length scale that marks a transition in rheology behavior of the melt with decreasing length scale of deformation i.e. with increasing process rate or decreasing temperatur...

A single-step, extrusion-based process to depolymerize poly(ethylene terephthalate) (PET) is being investigated. The depolymeriza tion is effected by reacting ethylene glycol (EG) with the high molecular weight polymer (glycolysis). The ethylene glycol causes chain scission by attacking the ester linkages along the polymer backbone. The objective is to recover purified low molecular weight olig...

Hot-melt extrusion is commonly applied for forming products, ranging from metals to plastics, rubber and clay composites. It is also increasingly used for the production of pharmaceuticals, such as granules, pellets and tablets. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also to possibly develop software sensors or cont...

Eight bioactive drug compounds (abamectin, amoxicillin, dexamethasone, dexamethasone valerate, ketoprofen, melatonin, oestradiol 17β, and oestradiol benzoate) were combined via melt extrusion and disc pressing processes with a polycaprolactone (PCL) matrix and were then evaluated and compared via membrane diffusion and Hanson dissolution studies. This investigation was to determine the potentia...

Over the decades with outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) has also expanded acceptance. As a result adaptability, it developed itself in wide range as part pharmaceutical research development. New drug entities face failures or delays during including poor biopharmaceutical properties, toxicities lack efficacy. To overco...