hydrogen bonding of dppe with water that surrounded of membrane, plays an important role in permeability ofmembrane that we were presented this matter with analysis of bond angles and torsion angles before and after ofadded water molecules.interaction with water molecules causes some changes in the geometry of dppe which were explained bythe contribution of zwitterionic form of dppe molecule, a...

Tight junctions are the most apical components of endothelial and epithelial intercellular cleft. In the endothelium these structures play an important role in the control of paracellular permeability to circulating cells and solutes. The only known integral membrane protein localized at sites of membrane-membrane interaction of tight junctions is occludin, which is linked inside the cells to a...

the physiologic function of the immune system is defense against infectious microbes and internal tumour cells, therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. the mammalian cellular cd200 (ox2)/cd200r interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. cd200 and cd200r molecules are membrane proteins that t...

Background: Inflammation is involved in development, progression, and complications of atherosclerotic disease. Clinical studies have indicated that the level of monocyte chemoattractant protein 1 (MCP-1), IL-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. Experimental studies have shown pentoxifylline (PTX) reduces these ...

We assess the cross-reactivity of both cellular as well as recombinant E- and N-cadherins using functionalized bead arrays assembled on atomic-force-microscope cantilevers. This new approach builds upon and enhances the utility of a recently developed force probe that integrates a custom-built, horizontal atomic force microscope with micropipette manipulation. It enables us to test multiple bio...

Background: Tissue engineering has been investigated as a potential method for healing traumatized tissues. Biomaterials are material devices or implants used to repair or replace native body tissues and organs. The present study was conducted to evaluate the effects of decontamination methods on biological/mechanical properties and degradation/adhesion test of the platelet‑-rich fibrin (PRF) m...

Cadherins impart strong cell-to-cell adhesion that nucleates the assembly of adherens junctions. Initial adhesion events organize a multi-protein, cytoskeletal complex at adhesion sites (Adams et al., 1996, 1998; McNeill et al., 1993). This adhesion complex grows rapidly, organizes the lateral plasma membrane, and helps generate polarized distributions of plasma membrane proteins (Yeaman et al....

Human pluripotent stem cells (hPSCs) are ideal “raw materials” for making various human cell types regenerative medicine and needed in large numbers. 3D suspension culturing (e.g., stirred-tank bioreactor or STR), which suspends cultures an agitated medium, has been extensively studied to scale up hPSC production. However, a significant problem with is the uncontrolled spheroid agglomeration. I...

Since their development approximately a decade ago, cell adhesion molecules have been attracting interest for a number of reasons. For example, the blockade of the interaction between leukocytes and the endothelium by agents that mimic or inhibit these adhesion molecules may provide the basis for a new class of therapeutic agents, although promising studies in animals1–3 have yet to be translat...