The inside of the fallopian tube is covered with epithelial cells. These cells are involved in the transportation of oocytes and sperms in the tube and are important for fertilization to occur. The hormone progesterone has been tested for its effect on the ciliary activity in the fallopian tube and previous studies have shown that progesterone reduces the ciliary beat frequency (CBF). There are...

In hypothalamic astrocytes obtained from adult female rats, estradiol rapidly increased free cytoplasmic calcium concentrations ([Ca(2+)](i)) that facilitate progesterone synthesis. The present study demonstrated that estradiol (1 nm) significantly and maximally stimulated progesterone synthesis within 5 min, supporting a rapid, nongenomic mechanism. The group I metabotropic glutamate receptor ...

245 International Journal of Pharmaceutical Compounding Vol. 6 No. 4 July/August 2002 Effects of Progesterone on Bone Current studies2 examining the role of progesterone on bone homeostasis indicate that the effects of progesterone are mediated by its nuclear receptors. In the 1970s, O’Malley et al2 showed that those receptors are composed of two receptor proteins, PRa and PRb, each of which bi...

background: malignant neoplastic lesions of the breast are one of the main causes of cancer death among women. several factors can be influential in the treatment process of breast cancer patients. the expression status of estrogen and progesterone receptors in tumor cells is among the most important determinants affecting the treatment approach and prognosis of these patients. in this paper, w...

background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...

These experiments examined the influence of estradiol and progesterone given in vivoon norepinephrine (NE) regulation of CAMP synthesis in hypothalamic and preoptic area slices in vitro. Administration of progesterone to estrogen-primed female rats attenuated NE-induced slice CAMP accumulation. This hormone-dependent reduction in NE-stimulated CAMP synthesis was observed in slices incubated wit...

Endocrine disruption compounds (EDC) are known to affect reproduction, development, and growth of exposed organisms. Although in vertebrates, EDCs mainly act through steroid receptors (e.g. androgen estrogen receptors), their absence many invertebrates suggests the involvement another biological pathway endocrine effects. As retinoid signaling is present almost all Metazoa its gastropods (i.e. ...

Progesterone exerts beneficial effects on the human cardiovascular system by inducing rapid increases in nitric oxide (NO) production in vascular endothelial cells, but the receptors mediating these nongenomic progesterone actions remain unclear. Using human umbilical vein endothelial cells (HUVECs) as a model, we show that progesterone binds to plasma membranes of HUVECs with the characteristi...

Expression of the oestrogen and progesterone receptors on uterine mucosal leukocytes has been examined by dual immunohistology. Neither the oestrogen receptor nor the progesterone receptor was expressed by lymphocytes, macrophages or the distinctive population of uterine natural killer (NK) cells. Although the accumulation and survival of these NK cells appears to be hormonally dependent, the e...

Introduction: Ovarian hyper-stimulation is widely used in IVF clinics. The main purpose of this method is to stimulate folliculogenesis and increase the number of oocytes in one cycle. Following ovarian hyper-stimulation, hormonal secretion of the ovary, particularly estradiol and progesterone dramatically increases. Immune cells especially dendritic cells have receptors for the estradiol...