The reports of glomerular lesions of kidney due to tuberculosis are sparse. A 48-year-old gentleman, presented with swelling of feet of 3 months duration. As he had renal impairment, proteinuria and normal-sized kidneys, he was subjected to renal biopsy. The light microscopy and immunofluorescence revealed the diagnosis was membrano-proliferative glomerulonephritis. During hospital stay, the pa...

A 4-year-old boy presented with proteinuria and developed progressive renal failure over 6 years. In the patient's family, five individuals were affected with atypical haemolytic uraemic syndrome (aHUS) but not the patient. Renal biopsies (n = 3) showed glomerular basement membrane thickening with double contours, endothelial swelling and deposits of C3 and C1q. Electron microscopy revealed mes...

Atypical hemolytic uremic syndrome (aHUS) associated with membranoproliferative glomerulonephritis (MPGN) is an uncommon clinical presentation, especially in children. We report a 8-year-old-boy who presented like aHUS but the kidney biopsy showed MPGN type 1.

Prediction of the histology of MPGN was performed without doing a renal biopsy by a univariate and multivariate analysis of three histological groups in nephrotic children: membranoproliferative glomerulonephritis (MPGN, N=13), proliferative glomerulonephritis (PGN, N=11) and minimal change nephrotic syndrome (MCNS, N=10). If the Y value of the following equation exceeded 0.41, the probability ...

Purpose To assess the evolution of retinal findings in patients with membranoproliferative glomerulonephritis (MPGN) by funduscopy, intravenous fluorescein angiography and optical coherence tomography. Observations Three women and one man were followed for a period of 1.5-37 years. Four patients (8 eyes) had drusen detected at first fundus exam at age 24, 29, 50 and 55. Three patients (6 eyes...

BACKGROUND Lymphoproliferative disorders causing paraproteinemia can be associated with various kidney injuries including the deposition of monoclonal immunoglobulins (Ig). A known glomerular manifestation of Waldenström's macroglobulinemia is characterized by prominent intracapillary hyaline thrombi and lack of conspicuous glomerular proliferation. The present case was special in 2 aspects: 1....

BACKGROUND MPGN is a light-microscopic ‘‘pattern of injury’’ caused by many disorders (see Table 20). Patients commonly present with nephrotic syndrome, hypertension, glomerular hematuria, and progressive kidney dysfunction. Reduction in the serum concentration of complement components (C3 and/or C4) is commonly, but not uniformly, observed. MPGN can be further classified based on the extent an...