نتایج جستجو برای: mendelian
تعداد نتایج: 7468 فیلتر نتایج به سال:
Theories of evolution . Variation of gene frequency . Simple Mendelian equilibrium . Mutation pressure . Migration pressure . Selection pressure . Equilibrium under selection . Multiple allelomorphs . Random variation of gene frequency . Rate of decrease in heterozygosis . The population number . The distribution of gene frequencies and its immediate consequences . No mutation, migration or sel...
The discovery of alleles that are able to distort segregation during meiosis in their favour raises the question of why Mendelian segregation is the rule and segregation distortion the exception. Previous research on this topic was limited by an unrealistic assumption: equal segregation in the two sexes. Ubeda and Haig [(2005) Genetics 170, 1345-1357] provide a new model allowing sex-specific s...
There is considerable interest in understanding genetic determinants of critical illness to improve current risk stratification models, provide individualized therapies, and improve our current understanding of disease mechanisms. This review provides a broad overview of genetic nomenclature, different study designs, and problems unique to each of these study designs in critical illnesses. Well...
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of the motor neurons. To date, 126 genes have been implicated in ALS. Therefore, the heterogenous genetic background of ALS requires comprehensive genetic investigative approaches. METHODS In this study, DNA from 28 Hungarian ALS patients was subjected to targeted high-throughput se...
Human diseases are caused by environmental factors (infections, malnutrition, poisons, or injuries), or genetic factors including single gene/Mendelian diseases, complex diseases (defects in multiple genes), and genomic diseases (chromosomal abnormalities). The focus is on Mendelian diseases which are characterized by: (1) rare alleles (<0.5% MAF, minor allele frequency) or very rare alleles (<...
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