The influence of 6-mercaptopurine and aminopterin was studied on immune response and immune thyroiditis in guinea pigs immunized with thyroid extract. 1. Both compounds depressed delayed hypersensitivity to thyroglobulin and immune thyroiditis. 2. Antibody formation to thyroglobulin was strongly depressed by aminopterin but not significantly influenced by 6-mercaptopurine. 3. Immune response an...

A series of selenium analogs of physiologically active thiopurines and thiopyrimidines has recent ly been prepared (9). The well established antitumor activity of some of the analogous mercapto compounds, particularly 6-mercaptopurine, which has enjoyed wide clinical use in the treatment of various types of leukemia (3,12), indicated the desirability of comparing the chemical and biologi cal pr...

A simple, rapid, specific, sensitive and liquid chromatography coupled with tandem mass spectrophotometric method was developed and validated for the estimation of azathioprine and its metabolite 6-mercaptopurine in human plasma by using lamivudine and 6-mercaptopurine D3 as the internal standard. Azathioprine and 6mercaptopurine were extracted from human plasma by solid-phase extraction (SPE)-...

6-Mercaptopurine and mitomycin C were used in combination drug therapy to produce a prolongation of skin allograft survival.

A nationwide study of intracellular drug metabolite concentrations in children prescribed 6-mercaptopurine for the treatment of lymphoblastic leukaemia was carried out to assess interpatient variability at a standardised dose. Nine children (2% of the total) had completely undetectable metabolites, indicative of non-compliance. Five were adolescents, but otherwise they had no obvious distinguis...

Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects occur in about 15% of patients. The main side effects are pancreatitis, allergic reactions, fever and bo...

Thiopurines, immunomodulating drugs used in the management of different chronic autoimmune conditions and as anti-leukemic agents, may exert some cases gastrointestinal toxicity. Moreover, since these agents are administered orally, they absorbed across tract epithelium. On premises, cellular molecular events occurring intestinal cells be important to understand thiopurine effects. However, qua...

The PRPP concentrations, PRPP formation, and phosphorylation of 6-mercaptopurine in leukocyte suspensions and homogenates prepared from leukemic patients were studied...