conclusions these findings suggested mes might be an important risk factor for chd, but not for mortality due to chd in patients on hd. objectives we examined the association between mes and its risk in terms of chd in patients on hemodialysis (hd). patients and methods this study was conducted on 300 patients on hd in six hd centers during march 2012. patients were divided in two groups regard...

Series of 3, 4-disubstituted benzaldehyde-N-(6-substituted-1,3-benzothiazol2-yl)semicarbazones (4a-t) were synthesized by condensation of the N(substituted-1,3-benzothiazol-2-yl)hydrazinecarboxamides with aromatic aldehydes and screened for their anticonvulsant activity using the maximal electroshock seizure (MES) method. The selected compounds were checked for the neurotoxicity by rotorod test...

A new series of chalconesemicarbazones was synthesized and evaluated for anticonvulsant activity by MES Method. Most of the compounds were found to be more or comparable potent than the reference standard drug in the acetic acid-induced writhing test.

A series of p-nitrophenyl substituted semicarbazones (4a-c) and phenoxy/p-bromophenoxy acetyl hydrazones (8a-q) were synthesized and their anticonvulsant activity was screened against maximal electroshock seizure (MES), subcutaneous metrazole (ScMet) and subcutaneous strychnine (ScSty) tests. Compounds 4a-c with -NHCO- were found to be the most active in all these tests. These compounds were al...

A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

A unique and essential feature of germ cells is their immortality. In Caenorhabditis elegans, germline immortality requires the maternal contribution from four genes, mes-2, mes-3, mes-4 and mes-6. We report here that mes-2 encodes a protein similar to the Drosophila Polycomb group protein, Enhancer of zeste, and in the accompanying paper that mes-6 encodes another Polycomb group protein. The P...

to determine the anticonvulsant activity of the leaf extract of croton zambesicus in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. the pentyleneterazole (ptz) and the maximal electroshock seizure (mes) models were used for assessing the anticonvulsant effects of the aqueous leaf extract in mice and rats. in the ptz test, the leaf extract (1...

objective: regarding the anticonvulsant effects of satureja hortensis (s. hortensis) in avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of s. hortensis aqueous and ethanolic aerial part extracts. furthermore, the mechanisms of their anticonvulsant activities were also evaluated. materials and methods: seizure was induced by pentylent...

BACKGROUND AND PURPOSE Transcranial Doppler ultrasound (TCD) can detect circulating microembolic signals (MES). We focused our attention on tail signs (TS), a signal associated with MES that appeared as a small reversal signal after MES on the high time resolution spectral display. We examined MES and artifacts in an animal study to determine whether TS were specific changes associated with MES...