نتایج جستجو برای: mesenchymal transition

تعداد نتایج: 307477  

Journal: :Journal of cell science 2016
Jonathan Bergeman Alexia Caillier François Houle Laurence M Gagné Marc-Étienne Huot

Epithelial-to-mesenchymal transition (EMT) is a process by which cancer cells gain the ability to leave the primary tumor site and invade surrounding tissues. These metastatic cancer cells can further increase their plasticity by adopting an amoeboid-like morphology, by undergoing mesenchymal-to-amoeboid transition (MAT). We found that adhering cells produce spreading initiation centers (SICs),...

2012
Jason C. Kovacic Nadia Mercader

Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a mesenchymal-toepithelial phenotype, are important biological programs that are operative from conception to death in mammalian organisms. Indeed, the capacity of cells to switch between these states has been fundamental to the generation of complex body patterns throughout evolution. Phenotypic switching from ...

Journal: :Circulation 2012
Jason C Kovacic Nadia Mercader Miguel Torres Manfred Boehm Valentin Fuster

Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a mesenchymal-toepithelial phenotype, are important biological programs that are operative from conception to death in mammalian organisms. Indeed, the capacity of cells to switch between these states has been fundamental to the generation of complex body patterns throughout evolution. Phenotypic switching from ...

Journal: :PLOS ONE 2021

Background The purpose of the present study was to evaluate relationship between chronic endometritis and epithelial-mesenchymal transition in endometrium infertile patients implantation phase. Methods Endometrial biopsy specimens from 66 infertility were analyzed. presence investigated by immunostaining for CD138. Immunohistochemical staining E-cadherin, N-cadherin, Slug, Snail performed, expr...

2013
Jan Roger Olsen Anne Margrete Oyan Kari Rostad Margrete R. Hellem Jie Liu Lisha Li David R. Micklem Hallvard Haugen James B. Lorens Varda Rotter Xi-Song Ke Biaoyang Lin Karl-Henning Kalland

The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT. We therefore investigated the role of p63 in EMT. Over-expression of the predominant epithelial isoform ΔNp63α in mesenchymal type cells of the model led to...

2009
Behrous Davani Sahar Ariely Laertis Ikonomou Yoram Oron Marvin C. Gershengorn

We showed previously that undifferentiated, proliferating human islet-derived precursor cells (hIPCs) are a type of mesenchymal stem/stromal cell (MSC) that can be induced by serum deprivation to form clusters and ultimately differentiate in vitro to endocrine cells. We also demonstrated that partially differentiated hIPC clusters, when implanted under the kidney capsules of mice, continued to ...

2016
Elizabeth J Sandquist Seema Somji Jane R Dunlevy Scott H Garrett Xu Dong Zhou Andrea Slusser-Nore Donald A Sens

BACKGROUND Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype. In cancer, epithelial to mesenchymal transition has been proposed to play an important role during specific stages of tumor progression. The role epithelial to mesenchymal transition and mesenchymal to epithelial trans...

2016
Giulia Chiabotto Stefania Bruno Federica Collino Giovanni Camussi

Mesenchymal-epithelial interactions play an important role in renal tubular morphogenesis and in maintaining the structure of the kidney. The aim of this study was to investigate whether extracellular vesicles (EVs) produced by human renal proximal tubular epithelial cells (RPTECs) may induce mesenchymal-epithelial transition of bone marrow-derived mesenchymal stromal cells (MSCs). To test this...

2017
Aristidis Moustakas Antonio Garcia de Herreros

The generation of an organized architectural pattern during tissue formation is a process of paramount importance during development and organogenesis. A large proportion of the vertebrate body is made of epithelial tissues; these provide organized barriers between organ compartments and also differentiate into glandular, secretory specializations (Kahata et al., 2017). One feature of epithelia...

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