BACKGROUND Most studies on the relationships between metabolic disorders (hypertension, dyslipidemia, and impaired glucose tolerance) and hepatic steatosis (HS) or visceral fat accumulation (VFA) have been cross-sectional, and thus, these relationships remain unclear. We conducted a retrospective cohort study to clarify the relationships between components of metabolic disorders and HS/VFA. M...

Some of the most common and debilitating conditions are metabolic disorders (metabolic syndrome non-alcoholic fatty liver disease) depression. These also exacerbated by fact that they often co-occur. Although exact mechanisms underlying such relationships poorly known, antipsychotic medication antidepressant use, diet physical activity, lifestyle factors believed to play a role; however, their ...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

PM 2.5 can cause adverse health effects via several pathways, such as inducing pulmonary and systemic inflammation, penetration into circulation, activation of the autonomic nervous system. In particular, impact exposure on liver, which plays an important role in metabolism detoxification to maintain internal environment homeostasis, is getting more attention recent years. present study, C57BL/...

background: patients with bleeding disorders are frequently infected with hepatitis c virus (hcv). there are few reports on the effect of standard interferon in these patients and no published report on pegylated interferon. the aim of this study was to compare pegylated interferon alpha-2a and standard interferon alpha with ribavirin in patients with bleeding disorders and chronic hcv infectio...

Growth hormone (GH) and glucocorticoids (GCs) are involved in the control of processes that are essential for the maintenance of vital body functions including energy supply and growth control. GH and GCs have been well characterized to regulate systemic energy homeostasis, particular during certain conditions of physical stress. However, dysfunctional signaling in both pathways is linked to va...

Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer. The pathogenesis of these diseases is extremely complex, multifactorial, and only partially understood. As the main metabolic organ, the liver is c...

Aquaglyceroporins are a group of the aquaporin (AQP) family transmembrane water channels. While AQPs facilitate passage water, small solutes, and gases across biological membranes , aquaglyceroporins allow glycerol, urea some other solutes. Thanks to their glycerol permeability, involved in energy homeostasis . This review provides an overview what is currently known concerning functional impli...