نتایج جستجو برای: metacaspase

تعداد نتایج: 151  

Journal: :Antimicrobial agents and chemotherapy 2013
Fazal Shirazi Michael A Pontikos Thomas J Walsh Nathaniel Albert Russell E Lewis Dimitrios P Kontoyiannis

The high mortality rate of mucormycosis with currently available monotherapy has created interest in studying novel strategies for antifungal agents. With the exception of amphotericin B (AMB), the triazoles (posaconazole [PCZ] and itraconazole [ICZ]) are fungistatic in vitro against Rhizopus oryzae . We hypothesized that growth at a high temperature (42°C) results in fungicidal activity of PCZ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Robin E C Lee Steve Brunette Lawrence G Puente Lynn A Megeney

In complex organisms, caspase proteases mediate a variety of cell behaviors, including proliferation, differentiation, and programmed cell death/apoptosis. Structural homologs to the caspase family (termed metacaspases) engage apoptosis in single-cell eukaryotes, yet the molecular mechanisms that contribute to nondeath roles are currently undefined. Here, we report an unexpected role for the Sa...

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