In 1945, Hoffman described the first case of lupus-like disease that appeared after treatment with sulfadiazine. Since then, more than 70 drugs have been implicated in the induction of this disease. Of these, hydralazine, procainamide, chlorpromazine, isoniazide, methyldopa, quinidine, and penicillamine are the most common. Patients affected by drug-induced lupus may have all the manifestations...

Background and objectives: Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy, both as a health care problem and as an economic burden on society. They are a common cause of short-term hospitalization, prolonged hospitalization and death, especially among the elderly. Spontaneous reporting of ADRs remains one the most effective methods for the detection of n...

Purpose: The study aimed to assess the depressant or antidepressant effects of several Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2) inhibitor meloxicam, and the non-selective COX-1 and COX-2 inhibitors lornoxicam, sodium metamizole, and ketorolac. The current literature data regarding such effects of these agents are scarce. Materials and methods...