A41-year-old man was referred for electrophysiological evaluation after recurrent syncope that occurred frequently during vigorous exercise. The patient had a complete, normal cardiological work up, including a resting ECG, an exercise stress test, and an echocardiogram. He reported that just before loss of consciousness, his heart was beating very fast. An electrophysiological study was perfor...

Whether reversibility in airway obstruction with beta-adrenergic stimulant is a significant determinant for the outcome was tested in 59 patients with pulmonary emphysema and chronic bronchitis. During four years of follow-up, 43 (73 percent) patients survived and 16 (27 percent) died. Initial VC. FVC, FEV1, and PaO2 were significantly smaller, and PaCO2 was significantly larger in nonsurvivors...

The incorporation of 14C-leucine into rabbit lung slices was monitored in the absence and presence of selected drugs and chemicals relevant to the perturbation of lung function and the development of lung disease. Known inhibitors of protein synthesis (cycloheximide and ricin) inhibited the incorporation of 14C-leucine. Marked inhibition was also recorded with the lung toxins paraquat and 4-ipo...

(1) Lung function should be adequate and stable before transfer. (2) Humidification of inspired air should be adequate before and during transport, particularly for patients with an endotracheal tube or tracheostomy. If secretions are sticky 2 ml ofwarm saline can be passed down the endotracheal tube or tracheostomy tube at frequent intervals. (3) Supplemental oxygen should be available. (4) Pa...

The specific airway conductance (Gaw/Vtg) of 4 normal subjects and 5 subjects with respiratory diseases was measured before and after inhalation of orciprenaline. There was an almost maximum increase in Gaw/Vtg within 3 to 4 minutes in both groups of subjects after inhalation of orciprenaline. From the observed relatively rapid bronchodilatation, it would appear that the increased Gaw/Vtg is pr...

OBJECTIVE To assess the utilization of leukotriene modifiers (LM) relative to national guidelines and to investigate possible emergency room utilization differences for LMs as monotherapy versus inhaled corticosteroid (ICS) monotherapy or combination ICS and LM therapy. METHODS The utilization of leukotriene modifiers (montelukast sodium, zafirlukast, and zileuton), concurrent inhaled steroid...

A molecular imprinted polymer (MIP) was computationally designed and synthesized for the selective extraction of metaproterenol (MTP), from human plasma. In this regards semi empirical MP3 and mechanical quantum (DFT) calculations were used to find a suitable functional monomers. On the basis of computational and experimental results, acrylic acid (AA) and DMSO:MeOH (90:10 %V/V) were found to b...

A molecular imprinted polymer (MIP) was computationally designed and synthesized for the selective extraction of metaproterenol (MTP), from human plasma. In this regards semi empirical MP3 and mechanical quantum (DFT) calculations were used to find a suitable functional monomers. On the basis of computational and experimental results, acrylic acid (AA) and DMSO:MeOH (90:10 %V/V) were found to b...

BACKGROUND Intergenic variations on chromosome 4q25, close to the PITX2 transcription factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult hearts express PITX2 and whether variation in expression affects cardiac function. METHODS AND RESULTS mRNA for PITX2 isoform c was expressed in left atria of human and mouse, with levels in right atrium and left and...