PURPOSE To analyze the cranial distribution of level II lymph nodes in patients with laryngeal cancer to optimize the elective radiation nodal target volume delineation. METHODS AND MATERIALS The most cranially located metastatic lymph node was delineated in 67 diagnostic CT data sets. The minimum distance from the base of the skull (BOS) to the lymph node was determined. RESULTS A total of...

INTRODUCTION Metastases to Delphian lymph node is rarely present in laryngeal malignancy. This report describes its frequency in patients with glottic cancer undergoing supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP). MATERIAL AND METHODS Fourteen patients (13 male and 1 female) with a mean age of 58 years underwent a SCPL with CHEP and functional bilateral neck ...

nineteen lymph node biopsies, 3 curetting, 15 blood samples obtained from patients with lymphadenitis and high titers of toxoplasma antibodies, and 27 tonsillar tissues removed from patients because of chronic tonsillitis were inoculated intraperitoneally into mice for isolation of toxoplasma gondii. toxoplasms were isolated from 5 lymph node biopsies, one curettage material, 2 tonsillar tissue...

Mechanisms about regulation of mRNAs, microRNAs (miRNAs), and long non-coding RNAs (lncRNA) in cervical lymph node metastatic laryngeal squamous cell carcinoma (LSCC) remained unclear. Two sets of three microarrays of mRNA, miRNA and lncRNA in fresh surgical LSCC samples were established, respectively from three paired tumor and adjacent normal mucosa epithelial tissues in cN + (Positive metast...

Cervical lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC), but its accurate assessment after sentinel node biopsy or neck dissection is often limited to the histopathological examination of only one or two sections. Previous our study showed the usefulness of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting kerati...

background : the axillary lymph node stage is one of the single most important determinants in the prognosis of breast cancer patients. the disadvantages of the two previous methods used for evaluating axillary node metastasis, i.e., axillary lymph node dissection and sentinel lymph node biopsy, have directed researchers to investigate new techniques for this purpose. the aim of the current stu...

Patients with mediastinal lymph node metastasis (N2) in squamous cell carcinoma (SqCC) of the lung have poor prognosis after surgical resection of the primary tumor. The aim of this study was to clarify predictive factors of the recurrence of pathological lung SqCC with N2 focusing on the biological characteristics of both cancer cells and cancer-associated fibroblasts (CAFs) in primary and met...

BACKGROUND c-MET has recently been identified as a promising novel target in non-small cell lung cancer (NSCLC). We detected the consistency of c-MET gene amplification in metastatic lymph nodes and tumor tissues of NSCLC patients and discuss the clinical application value of c-MET gene amplification in metastatic lymph nodes. METHODS Real-time fluorescent quantitative PCR was used to test tu...

Prognosis of cancers with lymph node metastasis is known to be very poor; however, it is still controversial whether metastatic potential can be evaluated by expression profiles of primary tumors. Therefore, to address this issue, we compared gene expression profiles of 24 esophageal squamous cell carcinomas (ESCCs) with extensive lymph node metastasis and 11 ESCCs with no metastatic lymph node...