we present a rare case with history of neurological symptoms due to multiple brain metastases and no urological symptoms. during patient evaluation for primary tumor, transitional cell carcinoma (tcc) of left renal pelvis was found. the patient underwent gamma knife stereotactic radio-surgery for the metastatic brain lesions. radical nephroureterectomy was performed, and a 4-cycle course of pac...

Nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. Unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. Here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. No hypertension and cushingoid features were seen. Serum alpha...

PURPOSE To assess the current treatment of metastatic renal cell carcinoma, focusing on medical treatment options. MATERIAL AND METHODS The most important recent publications have been selected after a literature search employing PubMed using the search terms: advanced and metastatic renal cell carcinoma, anti-angiogenesis drugs and systemic therapy; also significant meeting abstracts were co...

Background To establish a set of consensus statements for the management metastatic renal cell carcinoma, total 12 urologists and clinical oncologists from two professional associations in Hong Kong formed an expert panel. Methods Through series meetings using modified Delphi method, panelists presented recent evidence, discussed experiences, drafted on several areas focus regarding carcinoma. ...

Choroidal metastases from renal carcinoma are rare. Most reported cases describe a clear cell carcinoma histologic subtype. Metastatic tubulopapillary renal cell carcinoma to the choroid plexus is very exceptional.We report the case of a 31-year-old man with a history of tubulopapillary renal cell carcinoma who presented two years later with metastatic disease to lungs and presternal soft tissu...

Renal cell carcinoma (RCC) has widespread and unpredictable metastatic potential. The most common sites of metastatic RCC are the lungs, lymph nodes, bones, liver, and brain; however the soft tissue metastasis is rare (2,3). Here we report a 76-year-old male patient who had renal cell carcinoma presented with gluteal metastasis. To our knowledge this is the first renal cell cancer case with glu...

Metastasis to the thyroid gland from distant cancer is rare, and, in some cases, is a diagnostic challenge. Here, we report a case of metastatic renal cell carcinoma of the thyroid gland. A 77-year-old man presented with a neck mass detected about 1 month previously. He had undergone a right nephrectomy owing to renal cell carcinoma 14 years previously. Fine needle aspiration cytology showed a ...

Systemic therapy for first-line metastatic renal cell carcinoma has evolved toward immune checkpoint blockade combinations incorporating a PD-1/L1 inhibitor along with CTLA-4 inhibition or VEGF-targeted therapy. The new treatment paradigm that integrates immunotherapy treatment-naïve advanced creates therapeutic challenge clinicians including the optimal way to integrate multidisciplinary care ...

The purpose of this study is clarify the changes in histological grade between primary and metastatic lesions in renal cell carcinoma. A tota of 100 cases of renal cell carcinoma and their metastases were compared respectively. In 31 (31%) of the cases observed, metastatic lesions were observed to have higher grade of malignancy when compared to primary lesions. In 59 (59%) of the cases, metast...

INTRODUCTION Despite being reported rarely, renal cell carcinoma is the third most frequent neoplasm to metastasize to the head and neck region preceded only by breast and lung cancer. Little information exists regarding the presentation and work-up of metastatic renal cell carcinoma in the oral cavity. CASE PRESENTATION We report the case of a 63-year-old Caucasian man presenting with an ora...