breast cancer is the most common cancer in women except skin cancer. the common metastatic sites include lymph node, lung, liver and bone. however, metastasis to the bladder is extremely rare. to our knowledge, this is the first case of breast cancer metastasis to urinary bladder in jordan which is reported. nine years after the initial diagnosis of lobular breast carcinoma, the patient suffere...

Krukenberg tumor is a rare form of metastatic ovarian cancer which accounts for less than 2% all tumor. mostly occurs after the age 40 years and rarely found in younger group. It usually presents with bilateral involvement ovaries. when primary already advanced. Here we are presenting case 22 old female from stomach.

Cancers evolve as a result of the accelerated proliferation cancer cells in complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are master regulators any step development. The tumor is composed many cellular noncellular that contribute to evolution cells. Cancer-associated fibroblasts (CAFs) activated TME implicate progression metastasis dissemination thr...

Metastatic tumors account for 1% of all oral malignancies. Metastasis to jaw bones is common, particularly in the mandible, rare in the oral soft tissues, and account for only 0.1% of oral malignancies. The majority of metastatic cases (70%) reported in the literature have primary tumors located in the lung, breast, kidney, and colon. Metastasis is a biological complex process that involves det...

Abstract Despite continual progress in the technologies and regimens for cancer therapy, treatment outcome of fatal metastatic breast is far from satisfactory. Encouragingly, nanotechnology has emerged as a valuable tool to optimize drug delivery process therapy via preventing cargos degradation, improving tumor-targeting efficiency, enhancing therapeutic agents’ retention specific sites, contr...

AIM To investigate potential role of highly metastatic BL6-10 tumor cell-released exosomes (EXO) in transfer of metastatic activity into poorly metastatic tumor cell line F1. METHODS The highly metastatic B16 melanoma cell line (BL6-10) was generated in our laboratory. EXO from this cell line were isolated and amount of exosomal recovered proteins was measured using Bradford assay. For phenot...

Mucoepidermoid carcinoma (MEC) is the most
 common malignant tumor of salivary gland and
 most commonly seen in parotid. Oncocytic
 mucoepidermoid (OMEC) a rare
 subtype. Here, we aimed to present histological,
 immunohistochemical, and molecular results a
 28-year-old female patient followed for endometrial
 cancer, whether mass right parotid primary or metas...

Abstract Spermatocytic tumor is a rare testicular tumor, which originated from gonocytes. It characterized by the histological feature of tripartite composed large, medium, and lymphocyte-like small cells. well-known that spematocytic benign, thus good prognosis expected after simple resection. Metastatic spermatocytic extremely usually accompanied variants including sarcomatous changes anaplas...

meningioma is usually a benign central nervous system (cns) tumor. metastasis is rare; however if it does occur the most metastatic sites are the liver and lungs. here, two cases of cns meningioma with metastasis to cervical lymph nodes are reported. the first case, a 48 year-old man developed cervical lymph node metastasis nine years after primary tumor diagnosis. the second case, a 23 year-ol...