Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to diseases associated with aging, such as coronary atherosclerosis and pulmonary fibrosis, but the molecular mechanism underlying these findings remains unknown. Here we used functional lipidomics and transcr...

BACKGROUND The use of methamphetamine and other drugs among young adults has been a theme of growing interest and concern on the part of researchers and health associations. This paper reports recent use of methamphetamine and its relation with some demographic variables among substance users in west of Iran. METHODS This cross-sectional study was carried out on 559 substance users of Hamadan...

results result shows that there is a significant difference between methamphetamine addicts and narcotics addicts and non-addicts in self-regulation and affective control (p = 0.001). conclusions this finding indicates that low self-regulation and affective control is a risky factor in psychoactive drugs abuse. materials and methods in this causative-comparative study, 80 addicts (40 methamphet...

Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separation of rat pups as a model of early life stress. Rat pups were either handled a...

BACKGROUND Chronic methamphetamine abuse can lead to multiple health hazards. In particular, the substance is associated with devastating effects on oral health including symptoms such as rampant caries, gingiva inflammation, and xerostomia, whereby the term "Meth Mouth" occurs in the current literature. However, "Meth Mouth" pathology is primarily described on the basis of individual cases or ...

Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse. In animals, methamphetamine and related drugs are known to damage brain dopamine (DA) neurons, and this damage has recently been shown to be detectable in living nonhuman primates by means of positron emission tomography (PET) with [11C]WIN-35,428, a DA transporter (DAT) ligand. The present studies determ...

BACKGROUND Crystal methamphetamine has become a drug of widespread use. Previous reports describe myocardial infarction, pulmonary edema, and aortic dissection related to methamphetamine use. Cardiomyopathy due to methamphetamine exposure has been rarely described. METHODS We identified 1640 patients admitted in a 4-yr period with a primary or secondary diagnosis of cardiomyopathy. We exclude...

introduction:amphetamines are central nervous system (cns) stimulant substances and amphetamine abuse is considered a growing problem in our country. previous studies revealed destructive effects of amphetamines on metabolism, perfusion and structure of brain. the aim of current study was evaluating regional cerebral blood flow (rcbf) disturbances in methamphetamine (ma) abusers using brain per...

results the single covariance analysis of ancova indicated that the value of eta about 72% of variance of anxiety variable and about 76% of variance of drug abuse variable are taken in to account for variable of group. the intervention was effective in reducing anxiety and attitude to crack in males. evaluating the adjusted mean showed the effectiveness of matrix method on anxiety and attitude ...