Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects. Hence, need discovering novel compounds valuable clinical benefits is great importance. In this study, 18 derivatives p-nitrophenyl hydrazones were docked against COX-2, 5-LOX, H+/K+ ATPase, followed by predicting their drug-lik...

Rodlike two-component mixed crystals composed of 1-(5-methyl-2-phenyl-4-thiazolyl)-2-(5-methyl-2-p-tolyl-4-thiazolyl)perfluorocyclopentene (1a) and 1,2-bis(5-methyl-2-p-tolyl-4-thiazolyl)perfluoroc...

In the title compound, C(9)H(8)N(2)O(6), the methyl ester group is almost planar (r.m.s. deviation = 0.002 Å) and is oriented at a dihedral angle of 24.27 (16)° with respect to the benzene ring. The nitro groups make dihedral angles of 4.2 (5)° and 60.21 (11)° with the benzene ring. In the crystal, mol-ecules are linked by C-H⋯O inter-actions, resulting in zigzag chains.

The genus Ocimum L. belonging to family of Lamiaceae is widely distributed in Iran, Ocimum sanctum L. is described in many medicinal properties and a wide therapeutic range. It is used specially in the management of cough, ashtma, fever and common cold. In this research, samples were collected from Shahr-e-Rey, on August 2013, then essential oils were extracted by  hydro-distillation and steam ...

The contribution of free amino acids and thiamine to the production potent meat aroma compounds in nitrite-reduced, dry-fermented sausages inoculated with a D. hansenii strain was objective this study. For this, three different sausage formulations were manufactured; control two reduced by half nitrate nitrite one them hansenii. Free acids, content savoury volatile analysed. Eleven quantitated....

2- Methylsulfonyl - 5- (1-methyl-5-nitro- 2 – imidazolyl ) 1,3,4 - thiadiazole ( 1 ) was prepared by twa independent routes.1) reaction of 1-methyl-2-formyl-5- nitroimidazole (3) with methyl hydrazinecarbodithioate gave the hydrazone 4. Reaction of compound 4 with acetic anhydride followed by potassium permanganate oxidation of the intermediate 5 gave the desired compound 1. 2) React...

iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...