Expression of developmental and unconventional myosin heavy chain (MHC) isoforms in some adult head and neck muscles is thought to reflect specific contractile demands of muscle fibers active during kinematically complex movements. Mammalian tongue muscles are active during oromotor behaviors that encompass a wide range of tongue movement speeds and tongue shape changes (e.g. respiration, oral ...

Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic breeding strategies in animals. OBJECTIVES: MHC class II B genetic diversity and its association with humoral immune responses against Newcast...

Abstract Local intratumor delivery with electroporation of low levels plasmids encoding molecules, such as IL-12, IL-15, induces an antitumor effect without causing systemic toxicity. However, previous studies have predominately focused on the function delivered molecule encoded within plasmid, and ignored plasmid backbone. In this study, we found backbones pUMVC3 pVax1 induced up-regulation MH...

CD8 engagement is believed to be a critical event in the activation of naive T cells. In this communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the necessity of CD8 engagement in T cell activation of primary naive cells. Using two peptides with different measured avidities for the same pMHC-TCR complex, we compared biochemical affinity of pMHC/TCR and the cell surface ...

Abstract Background Immunotherapy is a promising therapeutic approach to fight cancer by activating the immune system. Multiple immune-based strategies are under development that aim at recruiting or re-activating cellular components of While immunotherapies have recently revolutionized therapy, they shown so far little success in glioblastoma patients. To enhance efficacy novel strategies, we ...

Zusammenfassung Unter Berücksichtigung der in den vorherigen Kapiteln erarbeiteten Rückschlüsse wird nun Bezug auf das Konzept Meaningful Human Control (MHC) genommen. Grundprämisse dieses Konzeptes ist es, menschliche Kontrolle über Systeme auch dann zu ermöglichen, wenn diese einen gewissen Grad an Autonomie aufweisen. Das meint nicht immer nur die akute ein spezifisches System. MHC basiert E...

Abstract MHC-II–mediated antigen presentation is essential for the function of immune system. Recent evidence indicates that MHC-II expression shapes tumor immunity and response to immunotherapy. expressing presenting cells (APCs) mediate CD4 +T-cell priming activation license them support CD8 response. Citrullination – catalyzed by peptidyl arginine deiminases (PADs) a post-translational modif...

Pancreatic ductal adenocarcinoma (PDAC) is among the world's deadliest cancers. Multiple studies demonstrated that PDAC frequently characterized by presence of Kirsten Rat Sarcoma (KRAS) G12D, G12V, and G12R protein mutants. The mutants are potential immunotherapy targets due to their as cancer-specific neoantigens. KRAS G12V contain vaccine-immunogenic epitopes. epitopes were presented at majo...