نتایج جستجو برای: mhc class ii

تعداد نتایج: 943960  

Journal: :Immunologic research 2010
Scheherazade Sadegh-Nasseri Sateesh Natarajan Chih-Ling Chou Isamu Z Hartman Kedar Narayan AeRyon Kim

T cells bearing alphabeta receptors recognize antigenic peptides bound to class I and class II glycoproteins encoded in the major histocompatibility complex (MHC). Cytotoxic and helper T cells respond respectively to peptide antigens derived from endogenous sources presented by MHC class I, and exogenous sources presented by MHC II, on antigen presenting cells. Differences in the MHC class I an...

Journal: :Journal of Korean Medical Science 1995

Journal: :Journal of immunology 2000
M P Peppelenbosch M DeSmedt G Pynaert S J van Deventer J Grooten

Macrophages present exogenous Ag either via MHC class I or MHC class II molecules. We investigated whether the mode of hemagglutinin (HA) uptake influences the class of MHC molecule by which this Ag is presented. Normally, HA is ingested by receptor-mediated endocytosis, but this may be switched to macropinocytosis and pinocytosis by adding phorbol esters to the cells. This switch resulted in a...

Journal: :Journal of immunology 1999
Y Itoh-Lindstrom J F Piskurich N J Felix Y Wang W J Brickey J L Platt B H Koller J P Ting

Class II transactivator (CIITA) is an unusual transcriptional coactivator in that it contains a functionally important, GTP-binding consensus domain. To assess the functional role of the GTP-binding domain of CIITA in vivo, we have generated knockout mice that bear a mutation in the CIITA gene spanning the GTP-binding domain. Upon analysis, these mice show no detectable CIITA mRNA; hence, they ...

2010
Kasper Winther Jørgensen Søren Buus Morten Nielsen

Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, allowing binding of peptides extending out of the binding groove. Furthermore, only a few HLA-DR all...

Journal: :Journal of immunology 2012
Amlan Biswas Torsten B Meissner Taro Kawai Koichi S Kobayashi

MHC class I and class II are crucial for the adaptive immune system. Although regulation of MHC class II expression by CIITA has long been recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5/class I transactivator. In this study, we show using Nlrc5-deficient mice that NLRC5 is required for both constitutive and inducible MHC cla...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Roger Belizaire Emil R Unanue

Peptides derived from exogenous proteins are presented by both MHC class I and II. Despite extensive study, the features of the endocytic pathway that mediate cross-presentation of exogenous antigens on MHC class I are not entirely understood and difficult to generalize to all proteins. Here, we used dendritic cells and macrophages to examine MHC class I and II presentation of hen egg-white lys...

Journal: :Journal of cell science 2010
Wilbert Zwart Victor Peperzak Evert de Vries Anna M Keller Gerda van der Horst Elise A M Veraar Ulf Geumann Hans Janssen Lennert Janssen Shalin H Naik Jacques Neefjes Jannie Borst

CD70 is a TNF-related transmembrane molecule expressed by mature dendritic cells (DCs), which present antigens to T cells via major histocompatibility complex (MHC) molecules. In DCs, CD70 localizes with MHC class II molecules in late endosomal vesicles, known as MHC class II compartments (MIICs). MIICs are transported to the immune synapse when a DC contacts an antigen-specific CD4(+) T cell. ...

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