Introduction Electrical stimulation of the brain is an important tool in the treatment of the neural disease. The major goal of this study is to develop a rodent model of Parkinson’s disease (PD) to explore the therapeutic mechanisms of deep brain stimulation (DBS). Indeed, the investment in DBS research has spanned a diverse range of topics from how to assess and quantify efficacy of DBS in re...

A monolithic CMOS microelectrode array (MEA) for stimulation and recording of electrogenic cells is presented. The chip features addressability of an arbitrary electrode subset for stimulation, complete on-chip signal conditioning and A/D conversion. The array has been fabricated using an industrial 0.6-μm, 5-V CMOS technology with a 2-mask post-CMOS processing. Measurements from neuronal and c...

In this research, a high performance silicon nanowire field-effect transistor (transconductance as high as 34 µS and sensitivity as 84 nS/mV) is extensively studied and directly compared with planar passive microelectrode arrays for neural recording application. Electrical and electrochemical characteristics are carefully characterized in a very well-controlled manner. We especially focused on ...

In this manuscript, we describe a biocompatible organic electrode system, comprising poly(3,4-ethylenedioxythiophene) (PEDOT) microelectrode arrays on indium tin oxide (ITO) glass, that can be used to regulate the neuron type, location, polarity, and outgrown length of neuron-like cells (PC-12). We fabricated a PEDOT microelectrode array with four different sizes (flat; 20, 50, and 100 μm) thro...

Field Potential Imaging Technology In article number 2207732, Ikuro Suzuki and co-workers demonstrate a large area field potential imaging technology using complementary metal–oxide–semiconductor (CMOS)-microelectrode array (MEA), present single-cell-level neural activity analysis of brain slices, human iPS cell-derived cortical networks, peripheral neurons, organoids. This detailed provides ne...

In this paper, we describe a novel approach for fabricating an optoelectrochemical microring array. The array was fabricated by coating individual optical fibers of 25-microm diameter with a 1-microm layer of gold nanoparticles via electroless gold deposition. A SAM layer around the individual gold-coated imaging fibers prevented electrical contact with neighboring ring electrodes. To achieve b...