A new method is presented for measurements of friction of microsized particles on surfaces. Specifically in this work, the particles are alumina with diameters between approximately 1 and 50 microm and the surfaces are InP, Si, and Cr. Friction is analyzed, its components are determined, and the friction coefficients are estimated from the experimental results. The technique and the specific in...

For proper folding, many proteins involved in signal transduction pathways, cell cycle regulation and apoptosis depend upon the ATP dependent molecular chaperone Hsp90. Consequently Hsp90 turned out to be an attractive target for cancer therapeutics. In this study we demonstrate the binding of the geldanamycin derivative 17 DMAG to Hsp90 using Microscale Thermophoresis (MST). The study also hig...

Integration of catalytic nanostructured platinum and palladium within 3D microscale structures or fluidic environments is important for systems ranging from micropumps to microfluidic chemical reactors and energy converters. We report a straightforward procedure to fabricate microscale patterns of nanocrystalline platinum and palladium using multiphoton lithography. These materials display exce...

A microscale chemistry improvement engine: a pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement. This platform allowed one chemist to set up 475 experiments and analyze the results using MISER chromatography in a single day, thus resulting in two high-quality catalytic systems for the construction of the title compound 1. Su...

Numerous materials show a softening behaviour at dynamic loading. The decrease of stress is caused by the evolution in the microscale in terms of areas where the local stiffness is reduced, e.g. due to micro-void growth. For a numerical treatment of this material behaviour, phenomenological damage approaches are used in daily engineering practice. For a better understanding of the micromechanic...

Microscale thermoelectric cooling elements (TECs) are being proposed to cool down an integrated circuit to maintain its performance. The maximum cooling power of microscale TECs is significantly reduced by the interfacial resistance. For our particular application, we calculate the optimal dimension of the TECs, made of Bi2Te3, that reduce the temperature at a hotspot on an IC chip by 10 C. By ...

Introduction Current clinical techniques to repair injured cartilage do not offer a long-term solution. Tissue engineering is viewed as a favorable option for long-term repair of cartilage lesions, but tissue engineered cartilage constructs generally have inferior mechanical strength compared to native cartilage. Researchers attribute this problem to a lack of an oriented structure in the const...

Propulsion at the microscale requires unique strategies such as the undulating or rotating filaments that microorganisms have evolved to swim. These features however can be difficult to artificially replicate and control, limiting the ability to actuate and direct engineered microdevices to targeted locations within practical timeframes. An alternative propulsion strategy to swimming is rolling...