Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/...

Background and Aim: We aimed to determine the prognostic imaging and clinical markers of chronic Post-Traumatic Sleep-Wake Disorders (PTSWDs) with a special focus on the early cognitive and executive dysfunctions following Traumatic Brain Injury (TBI). The prevalence rate of Post-Traumatic Psychiatric Disorders (PTPDs) in various sleep disorders was also investigated. Methods and Materials/Pat...

conceptually traumatic brain injury (tbi) can be classified from a mechanistic perspective as: 1) closed, 2) penetrating, 3) blast, and 4) crush injuries. thus, tbi is a heterogeneous disease and each type of brain injury has different characteristic features often necessitating different approaches to management. the first edition of the guidelines for management and prognosis of penetrating b...

25 26 It is estimated that about 1.5 million Americans suffer a traumatic brain injury (TBI) every year, of which 27 approximately 80% are considered mild injuries. Because symptoms caused by mild TBI last less than half an 28 hour by definition and apparently resolve without treatment, the study of mild TBI is often neglected resulting in 29 a significant knowledge-gap for this wide-spread pro...

Introduction: Mild chronic traumatic brain injury (TBI) causes behavioral deficits without changes to standard anatomical MRI. The event of mild TBI causes axonal shearing which disrupts the highly organized bundles of nerve fibers. Diffusion tensor imaging (DTI) is sensitive to water diffusion along or across these fiber bundles. Quantitative parameters of DTI such as fractional anisotropy (FA...

traumatic brain injury (tbi) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. the use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of tbi. in the present study, we surveyed the beneficial effec...

objective: to determine the prediction value of disorder of consciousness scale (docs) for consciousness recovery after traumatic brain injury (tbi) leading to coma. methods: this is a descriptive-cross-sectional study of the correlation between the level of patients’ consciousness in the first and second weeks and the first 2 months after traumatic brain injury, using docs scale. results: the ...

OBJECTIVE To index the frequency of reported chronic pain in patients with traumatic brain injury (TBI). DESIGN A case series study was conducted on consecutive patients with TBI. SETTING TBI patients were recruited from an adult tertiary care center brain injury clinic. PATIENTS A consecutive sample of 132 patients who attended a brain injury rehabilitation center after TBI. The sample i...

objectives this study evaluated the prevalence and characteristics of posttraumatic headaches attributed to mild brain injury in military personnel in isfahan. materials and methods a prospective, observational, descriptive study was conducted with a cohort of military personnel in military training during a 6-month period at the military training center in isfahan, iran. a total of 322 militar...

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among young adults. Substance abusers constitute a disproportionate percentage of these patients. A history of substance abuse predicts increased disability, poorer prognosis, and delayed recovery. While consensus in the literature indicates that substance-abuse rates decline following injury, conflicting literature show...