The neurodevelopmental hypothesis of schizophrenia proposes that impaired brain development is a cause of the illness. Early motor developmental milestones, such as learning to walk, are predictors of later schizophrenia but studies have not been systematically reviewed. The aim of the present systematic review and meta-analysis was to explore the association between early motor developmental m...

Being the last survivor a of the original triumvirate that launched the hairpin countercurrent theory of urine concentration, I thought it might be seemly for me to reminisce about how it came about 50 years ago. In 1946, I graduated in chemistry at the University in Budapest (Hungary) and became the lucky recipient of a fellowship offered by the University of Basel (Switzerland). A few months ...

Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical fiel...

L ymphangioleiomyomatosis (LAM), a slowly progressive disease affecting mostly young and middle-aged females [1], is one of the few orphan lung diseases that has attracted major attention in recent years from both clinicians and researchers [2], with rapidly evolving progress. With an estimated prevalence of one in 400,000 adult females aged 20–69 yrs for the sporadic form [3] and ,30% of patie...

The European Journal of Pediatric Surgery Reports (EJPS Reports) is releasing its 4th issue, the second of 2015. In the pastmonths EJPS Reportshas reached two important milestones as it builds a reputation for publishing highquality pediatric surgical case reports. In addition to being freely and immediately available online, all articles published in the journal are nowsearchable in PubMed tha...

OBJECTIVES To document the attainment of developmental milestones in children with Duchenne's muscular dystrophy (DMD) and to determine whether early delays are associated with later performance on measures of cognition. STUDY DESIGN Retrospective parental report was utilized to document the acquisition of 10 common developmental milestones in children with DMD (n = 130) and their unaffected ...

OBJECTIVE Little is known about the mental health outcomes of young children who experience developmental delay. The objective of this study was to assess whether delay in attaining developmental milestones was related to depressive and anxious symptoms in adolescence. METHOD The sample included 3508 Canadian children who participated in a nationally representative prospective cohort study. T...

Organizations are increasingly turning to outsourcing for software development, in part, to control cost and lower the likelihood of project failure. However, application outsourcing is not without risk. Milestones coupled with gateway reviews are a common mechanism for controlling these risks. Yet, the benefit of milestones must be assessed in light of their associated costs. This paper uses r...

OBJECTIVE To examine the predictive utility of demographic (illness status and SES), individual (neurocognitive functioning and intrinsic motivation), and family-based (parental intrusiveness) factors during adolescence on the achievement of emerging adulthood milestones in youth with and without spina bifida (SB). METHODS Questionnaire and observational data were collected from 14/15-year-ol...

Symbolic techniques and partial order reduction (POR) are two fruitful approaches to deal with the combinatorial explosion of model checking. Unfortunately, past experience has shown that symbolic techniques do not work well for loosely-synchronized models, whereas, by applying POR methods, explicit-state model checkers are able to deal with large concurrent models. This paper presents the Mile...