نتایج جستجو برای: mirwalk
تعداد نتایج: 77 فیلتر نتایج به سال:
Pancreatitis is a type of inflammation in the pancreas, which frequently occurs due to alcohol and gallstones. The present study aimed to identify pancreatitis‑associated microRNAs (miRNAs) by analyzing the microarray of GSE24279. GSE24279 was downloaded from the Gene Expression Omnibus, composed of a collective of 27 pancreatitis and 22 normal control samples. The differentially expressed miRN...
BACKGROUND Due to the poor prognosis for advanced renal cell carcinoma (RCC), there is an urgent need for new therapeutic targets and for prognostic markers to identify high risk tumors. MicroRNAs (miRNAs) are frequently dysregulated in tumors, play a crucial role during carcinogenesis and therefore might be promising new biomarkers. In previous studies, we identified miR-141-3p and miR-145-5p ...
AIM To identify multiple microRNAs (miRNAs) for predicting the prognosis of gastric cancer (GC) patients by bioinformatics analysis. METHODS The original microarray dataset GSE93415, which included 20 GC and 20 tumor adjacent normal gastric mucosal tissues, was downloaded from the Gene Expression Omnibus database and used for screening differentially expressed miRNAs (DEMs). The cut-off crite...
The influence of genetic factors may contribute to the poor prognosis of breast cancer (BC) at a very young age. However BRCA1/2 mutations could not explain the majority of cases arising in these patients. MicroRNAs (miRs) have been implicated in biological processes associated with BC. Therefore, we investigated differences in miRs expression between tumors from young patients (≤35 years) with...
Nasopharyngeal carcinoma (NPC) is prevalent in several regions, including. Southern China and Southeast Asia, with high mortality. The present study aimed to explore the epigenetic mechanisms of NPC and to provide novel biomarkers for prognosis. Two methylation data sets (GSE52068 and GSE62336) were downloaded from the Gene Expression Omnibus database. Following pretreatment of the raw data, di...
زمینه و هدف : با افزایش اندازه تومور، محیط سلولهای توموری هیپوکسیک و اسیدیک شده و سلولها شروع به افزایش تولید چندین نوع عامل رشد میکنند که در نتیجه آن تشکیل رگهای خونی موضعی آغاز میشود. به دنبال آن متاستاز سلولهای سرطانی از طریق عروق خونی اتفاق میافتد، لذا مهار رگزایی میتواند روش جدیدی برای درمان سرطان باشد. این مطالعه به منظور آنالیز بیوانفورماتیکی برای پیشبینی میکرو RNA های بالقوه مه...
Introduction: Considering the limitations of the common diagnostic test for prostate cancer prostate cancer, the introduction of higher-specific biomarkers for a more accurate and timely diagnosis of prostate cancer is desired. In this study, we aimed to investigate the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) and their target genes using bioinformatics prediction too...
Introduction: Considering the limitations of the common diagnostic test for prostate cancer prostate cancer, the introduction of higher-specific biomarkers for a more accurate and timely diagnosis of prostate cancer is desired. In this study, we aimed to investigate the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) and their target genes using bioinformatics prediction too...
Background: Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. In various cancers, miRNAs can act as oncogenes, tumor suppressors, or control the metastasis process by modulating the expression of numerous target genes. This study is aimed at determining molecular network of miRNA-mRNA regulating lung cancer invasion, by bioinformatics approaches. ...
Background and Objective: Tamoxifen is the most commonly used treatment for the patients with breast cancer called ER +, which prevents the expression of genes that are effective in the growth and proliferation of cancer cells by estrogen. Resistant to Tamoxifen is a major clinical problem in breast cancer treatment. In recent studies, the role of microRNAs in tamoxifen resistance has been rais...
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