Because of their high-energy metabolism, neurons are strictly dependent on mitochondria, which generate cellular ATP through oxidative phosphorylation. The mitochondrial genome encodes for critical components of the oxidative phosphorylation pathway machinery, and therefore, mutations in mitochondrial DNA (mtDNA) cause energy production defects that frequently have severe neurological manifesta...

The dispersal of modern humans across the globe began ~65,000 y ago when people first left Africa and culminated with the settlement of East Polynesia, which occurred in the last 1,000 y. With the arrival of Polynesian canoes only 750 y ago, Aotearoa/New Zealand became the last major landmass to be permanently settled by humans. We present here complete mitochondrial genome sequences of the lik...

the autism spectrum disorders (asd) are amongst the most heritable complex disorders. although there have been many efforts to locate the genes associated with asd risk, many has been remained to be disclosed about the genetics of asd. scrutiny's have only disclosed a small number of de novo and inherited variants significantly associated with susceptibility to asd. these only comprise a s...

................................................................................................. 6 List of papers .......................................................................................... 7 Populärvetenskaplig Sammanfattning ................................................... 8 Abbreviations .........................................................................................

Mushrooms that are morphologically indistinguishable from Russula virescens (Schaeff.) Fr. are among the most popular wild edible mushrooms in Yunnan province, southwestern China. However, almost nothing is known about their biology. This study investigated the diversity and population genetics of a R. virescens ally from Yunnan. A total of 210 samples were collected from 13 geographical locati...

With the sequencing of the entire mitochondrial genome for some species, including Arabidopsis thaliana, Brassica napus, Beta vulgaris, Marchantia polymorpha, Oryza sativa, and Zea mays it is promising to explore the molecular genetics of mitochondrial respiratoryrelated genes in relation to some special traits with an emphasis on cytoplasmic male-sterility unique to plant mitochondria. Mitocho...