BACKGROUND The role of tumor necrosis factor-α (TNF-α), Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, and mitochondrial Permeability Transition Pore in atorvastatin-induced cardioprotection were examined in human myocardium, in vitro. METHODS Isometric force of contraction of human right atrial trabeculae was recorded during 30-min hypoxia and 60-min reox...

Reactive oxygen species (ROS) can trigger a transient burst of mitochondrial ROS production via ROS activation of the mitochondrial permeability transition pore (MPTP), a phenomenon termed ROS-induced ROS release (RIRR). The goal of this study was to investigate if the generation of ROS in a discrete region of a cardiomyocyte could serve to propagate RIRR-mediated mitochondrial depolarizations ...

Mitochondria play a fundamental role in the functioning of body but are also responsible for dysfunction, apoptosis, and death, associated with mPTP (mitochondrial permeability transition pore) opening. Despite fact that there many articles on this topic, none them solve problem PTP identification. The opening is elicited by matrix Ca2+ stimulated binding cyclophilin D (CyPD), Pi, elevated conc...