Our study was aimed at exploring the roles of lncRNA RP11-400K9.4 (RP11-400K9.4) on hypoxia/reoxygenation (H/R) -induced cardiomyocytes apoptosis. H/R model constructed in rat primary (PC) and H9c2 cells. In this study, results showed that significantly induced apoptosis PC The expression upregulated H/R-induced cells, but miR-423 downregulated. Silencing could attenuate We also found a potenti...

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α. p38α was activated and formed a disulfide-bound heterodimer with MAP2K3 (MKK3) in rat cardiomyocytes and isolat...

objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...

Mitogen-activated protein kinase (MAPK) is an important component of the signal transduction pathway, which plays roles in regulating plant growth and development, abiotic stress. Potato (Solanum tuberosum L.) one most popular tuber crops world. Genome-wide identification analysis MAPK MAPKK gene family potato not clear. A total 20 genes 8 were identified genome. conservative motif showed that ...

Like in other eukaryotic organisms, mitogen-activated protein (MAP) kinase cascades play important roles in response to host and environmental signals in fungal pathogens. In general, mitogen-activated protein kinase (MAPK) is activated by phosphorylation at the well-conserved threonine-x-tyrosine (TXY) motif by mitogen-activated protein kinase (MEK), which is in turn activated by mitogen-activ...

OBJECTIVE During myocardial ischemia-reperfusion injury, p38 mitogen-activated protein kinase is activated. We examined the effect of a highly specific inhibitor of p38 mitogen-activated protein kinase, FR167653, in an experimental model of regional myocardial ischemia-reperfusion. METHODS CD-1 mice received FR167653 intraperitoneally 24 hours before 30 minutes of transient occlusion of the l...