Our previous study showed that circulating microvesicles (cMVs) of diabetic mice have negative effects on the function of endothelial progenitor cells (EPCs). Whether this is true in diabetic patients deserves further study. In this study, the effects of cMVs and EPC-derived MVs (EPC-MVs) on EPC migration, apoptosis, and reactive oxygen species (ROS) production in healthy controls, well-control...

Several studies indicate that adult stem cells may improve the recovery from acute tissue injury. It has been suggested that they may contribute to tissue regeneration by the release of paracrine factors promoting proliferation of tissue resident cells. However, the factors involved remain unknown. In the present study we found that microvesicles (MVs) derived from human liver stem cells (HLSC)...

Several studies demonstrated that treatment with mesenchymal stem cells (MSCs) reduces cisplatin mortality in mice. Microvesicles (MVs) released from MSCs were previously shown to favor renal repair in non lethal toxic and ischemic acute renal injury (AKI). In the present study we investigated the effects of MSC-derived MVs in SCID mice survival in lethal cisplatin-induced AKI. Moreover, we eva...

Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way of cell-to-cell communication. We have recently shown that microglia, the immune cells of the brain, shed MVs upon activation but their possible role in microglia-to-neuron communication has never been explored. To investigate whether MVs affect neurotransmission, we analysed spontaneous release of glutamat...

BACKGROUND Cell-derived microvesicles (MVs) have been described as a new mechanism of cell-to-cell communication. MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling functional mRNAs. The aim of the present study was to evaluate whether MVs...

Since motion estimation via block matching is an ill-posed problem, it requires the use of smoothness constraints to regularize the motion field. The block matching error and smoothness constraints together form an energy expression to be minimized. Motion vectors (MVs) from a candidate set are used to determine which MV minimizes the overall energy. These MVs, which may consist of spatial or t...

This paper reports the development of methods for calculating a ventilation performance metric that is a measure of the airflow pattern in a room or zone of a multi-zone ventilation system. Temporal mixing theory is used as the basis for these methods. The methods are applicable to all ventilated systems that can be modeled as a set of interconnected chambers. Relations between the ventilation ...

Oracle Materialized Views (MVs) are designed for data warehousing and replication. For data warehousing, MVs based on inner/outer equijoins with optional aggregation, can be refreshed on transaction boundaries, on demand, or periodically. Refreshes are optimized for bulk loads and can use a multi-MV scheduler. MVs based on subqueries on remote tables support bidirectional replication. Optimizat...

Health care facility ventilation design greatly affects disease transmission by aerosols. The desire to control infection in hospitals and at the same time to reduce their carbon footprint motivates the use of unconventional solutions for building design and associated control measures. This paper considers indoor sources and types of infectious aerosols, and pathogen viability and infectivity ...

This study explores the assumption that 81mKr static images represent regional ventilation. Dynamic acquisition of 81mKr ventilation images permits creation of time-activity curves and the possible separation of the confounding influences of ventilation and volume. By using a two-compartment gas mixing lung phantom, the results demonstrate that both total and tidal 81mKr are closely related to ...