The marked tissue remodelling associated with luteolysis involves increased expression and activity of matrix metalloproteinases (MMPs) and an influx of immune cells, notably macrophages. Since the corpus luteum expresses high concentrations of specific tissue inhibitors of MMPs, it is clear that it is not only the increased activity of MMPs that is important, but also their tissue localization...

objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. MMPs have been shown to play critical roles in tumor cell invasion and metastasis. We verified the activity of MMPs in the sera and in the urine of patients with kidney carcinoma by gelatin zymo...

Neurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals reported to downregulate both the nuclear factor erythroid 2-related 2 (Nrf2) pathway antioxidant enzymes regulated by it, mediating OS induction neurodegeneration. Among a recently discovered fam...

The imbalance in the expression of matrix metalloproteinases (MMPs) and lysyl oxidases (LOXs) synovial fibroblasts (SFs) caused by mechanical injury inflammatory response prevents injured anterior cruciate ligaments (ACLs) from self-healing. However, research on effect growth factors SFs regulating microenvironment is limited. In this study, exogenous transform factor-β1 (TGF-β1) were employed ...

Mitochondrial myopathy patients (MMPs) have impaired oxidative phosphorylation and exercise intolerance. Endurance training of MMPs improves exercise tolerance, but also increases mutational load. To assess the regulation of mitochondrial content in MMPs, we measured proteins involved in 1) biogenesis, 2) oxidative stress, and 3) apoptosis in MMPs and healthy controls (HCs) both before and afte...

BACKGROUND Matrix metalloproteinases (MMPs) are evolutionarily conserved and multifunctional effector molecules in development and homeostasis. In spite of previous, intensive investigation in vitro and in cell culture, their pleiotrophic functions in vivo are still not well understood. METHODOLOGY/PRINCIPAL FINDINGS We show that the genetically amenable beetle Tribolium castaneum represents ...

The article by Carrel et al 1 in the present issue of Circulation provides remarkable new insights into the matrix metalloproteinases (MMPs) and their effects on the remodeling of the vascular system in aortic atherosclerotic and aneurysmal lesions. The MMPs constitute a family of endopeptidases that have in common the presence of zinc in their active site, a dependency on Ca for their activity...

Remodelling of the extracellular matrix (ECM) and cell surface by matrix metalloproteinases (MMPs) is an important function of monocytes and macrophages. Recent work has emphasised the diverse roles of classically and alternatively activated macrophages but the consequent regulation of MMPs and their inhibitors has not been studied comprehensively. Classical activation of macrophages derived in...